Table 2.

Parameter values for the activation and inactivation variables appearing in Equations 1315a

INaPIAIKILVAIHVAISIh
mhmh1h2mmhmh1h2mh1h2
Vh (mV)−41.5−47.4−29.4b−60b−60b−19.7b−51.4b−80.1b−11b−36.6b−36.6b−45−77.4−77.4
k (mV)−3.08.2−6.64b4.26b4.26b−12.3b−4.07b5.5b−7b14.6b14.6b−129.29.2
τ (ms)0.4Eq. 14Eq. 147.67b100bEq. 14Eq. 14250b0.816b53.4b728b1500Eq. 15Eq. 15
a67.3−2.91b23.8b31.3b−89.8−82.6
b−27.525.6b18b10.1b11.625.7
c67.365.3b23.8b31.3b35.8370.9
d27.5−10.6b−18b−10.1b7.654.1
e574.5110.6b109b
f62.60.0527b00.0391b
  • aVh and k are the voltage at half-activation or inactivation and the steepness of the steady-state function. τ is the time constant that is voltage-independent for mNap, h1A, h2A, hLVA, mHVA, h1HVA, h2HVA, and ms. For hNaP, mA, mK, mLVA, h1h, and h2h, τ is voltage-dependent and governed by Equation 14 (a, b, c, and d are in mV, e and f are in ms) or Equation 15 (a and b are in mV, and c is in ms).

  • bParameters that were reestimated from Moran et al. (2016).