Table 1.

Summary of the findings involved in the signaling pathway of systemic, central, or peripheral fentanyl-induced hyperalgesia and priming

Opioid hyperalgesiaCentral PGE2Peripheral PGE2
Central fentanyl
    Protein translationNE−+
    Src and MAPKNE+−
    MOR+++
    Peptidergic−+−
    Nonpeptidergic−+−
    Pep and nonpeptidergic+−−
    Calcium+++
Peripheral fentanyl
    Protein translationNE−+
    Src and MAPKNE+−
    MOR+++
    Peptidergic++−
    Nonpeptidergic−−−
    Pep and nonpeptidergic+++
    Calcium+++
Systemic fentanyl
    Protein translationNE−+
    Src and MAPKNE+−
    CalciumNE++

  • +, Involved in the priming mechanism; −, not involved in the priming mechanism; NE, not evaluated.