Table 3.

Single-channel properties of α1A384Pβ receptorsa

α1βα1A384Pβpb
Open probability0.80 ± 0.030.24 ± 0.070.0027
Mean open time, ms93.2 ± 13.448.2 ± 9.110.0197
Main conductance, pS37.9 ± 1.5535.4 ± 3.400.5069
pc
Open time constants
    τO1, ms3.74 ± 0.382.75 ± 0.240.9110
    τO2, ms33.8 ± 8.1443.2 ± 7.84
    τO3, ms130 ± 14144 ± 32
    aO1, %16 ± 333 ± 100.0003
    aO2, %25 ± 958 ± 9
    aO3, %59 ± 1314 ± 3

  • ↵aData are mean ± SEM (n = 6).

  • ↵bUnpaired two-tailed Student's t test relative to WT α1β receptors.

  • ↵cTwo-way ANOVA with Sidak's multiple comparisons test relative to WT α1β receptors.