Table 3.

AP properties of FS neurons in PFC

Stimulation protocol	Genotype	No. of neurons/mice	AHP (mV)	Threshold (mV)	AP peak amplitude (mV)	AP half-width (ms)	Maximum rise slope (mV/ms)	Maximum decay slope (mV/ms)
Current injection of 500 ms at rheobase	WT–VEH	17/5	22.55 ± 0.75	−38.13 ± 0.51	61.46 ± 1.57	0.50 ± 0.01	255.83 ± 11.37	−159.38 ± 7.06
	WT–TAM	14/3	24.17 ± 0.74	−37.56 ± 1.18	60.98 ± 1.95	0.48 ± 0.01	248.11 ± 10.68	−179.13 ± 7.84
	AS–VEH	15/6	22.75 ± 1.25	−36.54 ± 0.65	55.19 ± 1.74	0.61 ± 0.02	183.39 ± 13.65	−118.98 ± 8.02
	AS–TAM	25/5	22.57 ± 0.59	−37.50 ± 0.66	61.20 ± 1.40	0.51 ± 0.01	226.44 ± 9.73	−158.6 ± 5.57
Statistics
Two-way ANOVA (genotype × treatment) F/p values			F₍_1,68) = 0.83, p = 0.36	F₍_1,68) = 0.38, p = 0.35	F₍_1,68) = 4.51, p = 0.03	F₍_1,68) = 6.93, p = 0.01	F₍_1,68) = 4.31, p = 0.04	F₍_1,68) = 1.57 p = 0.21
Post-hoc Bonferroni p values
AS–VEH versus WT–VEH					0.0001	0.001	0.0001
AS–VEH versus WT–TAM					0.0001	0.004	0.0001
AS–VEH versus AS–TAM					0.0001	0.0001	0.05
Current injection of 1 ms and 1 nA	WT–VEH	17/5	19.39 ± 0.94	−43.92 ± 0.97	69.96 ± 2.15	0.49 ± 0.01	297.42 ± 14.46	−175.15 ± 9.23
	WT–TAM	14/3	18.76 ± 1.01	−45.10 ± 1.30	69.65 ± 2.13	0.46 ± 0.01	316.21 ± 10.87	−198.49 ± 8.18
	AS–VEH	15/6	21.60 ± 1.33	−39.53 ± 1.57	62.09 ± 2.77	0.56 ± 0.01	234.81 ± 14.54	−133.58 ± 7.06
	AS–TAM	25/5	20.17 ± 0.67	−44.42 ± 0.63	72.22 ± 1.05	0.47 ± 0.01	310.29 ± 6.24	−190.11 ± 6.22
Statistics
Two-way ANOVA (genotype × treatment) F/p values			F₍_1,68) = 0.13, p = 0.70	F₍_1,68) = 5.78, p = 0.019	F₍_1,68) = 10.30, p = 0.002	F₍_1,68) = 8.08, p = 0.006	F₍_1,68) = 9.64, p = 0.003	F₍_1,68) = 8.06 p = 0.006
Post-hoc Bonferroni p values
AS–VEH versus WT–VEH				0.03	0.005	0.0001	0.0001	0.0001
AS–VEH versus WT–TAM				0.011	0.035	0.0001	0.0001	0.0001
AS–VEH versus AS–TAM				0.001	0.001	0.0001	0.0002	0.0003