Table 4.

GO classification of down-regulated genesa

GO termDescriptionp valueFDR q valueEnrichment
GO:0008010Structural constituent of chitin-based larval cuticle8.27E-182.02E-1415.26
GO:0042302Structural constituent of cuticle2.15E-172.62E-1413.37
GO:0005214Structural constituent of chitin-based cuticle1.19E-169.7E-1413.53
GO:0005261Cation channel activityb3.34E-102.03E-77.25
GO:0022843Voltage-gated cation channel activityb7.15E-103.48E-713.78
GO:0005216Ion channel activityb9.33E-103.79E-75.89
GO:0022838Substrate-specific channel activity1.8E-96.26E-75.67
GO:0005198Structural molecule activity3.1E-99.46E-73.23
GO:0022836Gated channel activity3.64E-99.84E-77.35
GO:0046873Metal ion transmembrane transporter activity7.05E-91.72E-65.22
GO:0022803Passive transmembrane transporter activity1.08E-82.39E-65.09
GO:0015267Channel activityb1.08E-82.19E-65.09
GO:0022832Voltage-gated channel activityb1.34E-82.51E-610.67
GO:0005244Voltage-gated ion channel activityb1.34E-82.33E-610.67
GO:0008324Cation transmembrane transporter activity2.06E-73.35E-53.55
GO:0015075Ion transmembrane transporter activity2.72E-74.15E-53.00
GO:0022891Substrate-specific transmembrane transporter activity6.25E-78.95E-52.81
GO:0022890Inorganic cation transmembrane transporter activity9.3E-71.26E-43.65
GO:0022892Substrate-specific transporter activity2.26E-62.9E-42.52
GO:0015085Calcium ion transmembrane transporter activity7.21E-68.78E-47.56
GO:0022857Transmembrane transporter activity7.67E-68.9E-42.42

  • ↵aGO classification of the molecular function of the genes downregulated upon IP3R knockdown was performed using Gene Ontology enRIchment anaLysis and visuaLizAtion tool (GORILLA). Enriched categories with associated fold enrichment, p value, and FDR corrected q value are indicated.

  • ↵bVarious categories related to voltage-gated ion channels were identified.