Table 5.

Cortical target neurons of LRN TV77q

Target IDLocationDomainPVSATB1mGluR1aEndobiotin
S53A1aCA3 SOs(+)u+
S53A2ad+u+u
S53B1bs(+)+++
S53B2bd+u+u
S53Cd+u+u
S53Dd+u+u
S53Ed+u+u
S53Fd+u+u
S53Gd+u+u
S53Hdu+u
S53Id+u+u
S53Jd+u+u
S53Kd+++(+)
S53Ld+u+u
S52Ds(+)+(+)u
S52ACA3 SO /DG PMLds+++(+)
S50ACA3 SPds+++
S50Bd+u+u
S50Cd+uuu
S48ACA3d SR/SLMds++++
S52BDG PMLd(+)+(+)(+)
S52Cd(+)++(+)
S52Ed+uuu
S47Bd+uu+
S44Aduu(+)
S49ADG PML/GCLds(+)uuu
Total +22/23 (24/25)7/1018/18 (20/20)10/10
  • Molecular profiles of presumed postsynaptic neurons, based on close apposition of axon terminals.

  • +, Detectable positive immunoreactivity or signal; −, undetectable immunoreactivity or signal in vicinity of immunopositive signals; u, unknown (unavailable or inconclusive). Parentheses indicate weak immunoreactivity or signal. Domain, target subcellular domain (s, soma; d, dendrite).

  • a,bMSDB terminals were apposed to one or both of these targets in both cases and the targets themselves were in apparent contact; this affects the totals. Because many targets were onto thin distal dendrites, we cannot rule out that in some cases the target dendrites originated from the same neuron. Target S48A was also SOM+ and CB.