Regular ArticleA Comparative Study of Apoptosis and Necrosis in HepG2 Cells: Oxidant-Induced Caspase Inactivation Leads to Necrosis
References (37)
- et al.
FEBS Lett.
(1986) - et al.
Toxicol. Appl. Pharmacol.
(1997) - et al.
TiPS
(1989) - et al.
Biochem. Biophys. Res. Commun.
(1997) - et al.
Cell
(1996) - et al.
TiBS
(1997) - et al.
Cell
(1997) - et al.
J. Biol. Chem.
(1982) - et al.
Free Radical. Biol. Med.
(1997) - et al.
Arch. Biochem. Biophy.
(1984)
Neuron
J. Biol. Chem.
FEBS Lett.
Biochem Pharmacol.
FEBS Lett.
FEBS Lett.
Biochem. Biophys. Res. Commun.
FEBS Lett.
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2018, Archives of Biochemistry and BiophysicsMolecular mechanisms of leptin and pro-apoptotic signals induced by menadione in HepG2 cells
2014, Saudi Journal of Biological SciencesCitation Excerpt :The results showed that 10 μM menadione apoptotic action is mediated by inducing oxidative stress in HepG2 cells, while treating the cells with NAC inhibited menadione ROS generation effect in this study, the result agreed with study of Chen and Cederbaum (1997), also is supported by data of Koka et al. (2010) who found that pretreatment prostate cancer cell with NAC suppressed thymoquinone- ROS generation inducing and growth inhibition effects. Although the current study confirmed that menadione suppresses the cell viability by activation caspase-3 and ROS pathways, but in contrast Samali et al. (1999) found that menadione inactivates caspase by the generation of H2O2 which may prevent cell death. The results concluded that menadione has a dose and time dependent anti- viability effect by suppressing leptin pathway and activation caspase 3 and P53 signals depending on ROS generation.
Novel o-naphthoquinones induce apoptosis of EL-4 T lymphoma cells through the increase of reactive oxygen species
2013, Toxicology in VitroCitation Excerpt :As expected, the increase in the level of the active form of caspase 3 occurred after the proteolytic activation of caspase 9 and prior to the cleavage of PARP, showing that these events are sequential. β-Lapachone, an o-naphthoquinone, proved to be an effective cytostatic agent against different tumor cells, such as murine leukemia, melanoma, and hepatoma cells and human leukemia, colon carcinoma, lymphoma, and glioma cells, as well as epidermoid laryngeal, ovarian, breast, lung and prostate cancer cells (Dolan et al., 1998; Frydman et al., 1997; Li et al., 1993, 1995, 1999b; Pardee et al., 2002; Planchon et al., 1999; Samali et al., 1999). Based on these effects, the clinical use of β-lapachone has been suggested (Pardee et al., 2002), and the synthesis of a number new of o-naphthoquinones, such as NQs, has been pursued (Ferreira et al., 2011).
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