Biochemical and Biophysical Research Communications
Regular ArticleCathepsin B-Mediated Activation of the Proinflammatory Caspase-11☆
References (36)
- et al.
Cell
(1997) - et al.
Cell
(1995) - et al.
Cell
(1998) - et al.
J. Biol. Chem.
(1996) - et al.
J. Biol. Chem.
(1996) - et al.
Cell
(1996) - et al.
Cell
(1996) - et al.
Cell
(1997) - et al.
FEBS Lett.
(1997) - et al.
J. Chromatogr. A
(1994)
Gene
Anal. Biochem.
Cell
J. Biol. Chem.
J. Biol. Chem.
J. Biol. Chem.
J. Biol. Chem.
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Abbreviations used: Ac-YVAD.cmk, acetyl-Tyr-Val-Ala-Asp(Ome)-cmk; AFC, 7-amino-4-trimethyl coumarin; AMC, 7-amino-4-methyl coumarin; Apaf, apoptotic protease activating factor; CASP, caspase; CFS, cell free system; cmk, chloromethyl ketone; EST, expressed sequence tag; fmk, fluoromethyl ketone; HM, heavy membrane fraction; IL-1;gb:interleukin-1;gb; LPS, lipopolysacharide; PAGE, polyacrylamide gel electrophoresis; PCR, polymerase chain reaction; PMSF, phenylmethylsulphonyl fluoride; TNF, tumor necrosis factor; TNF-R, TNF receptor; TPCK, N-;ga-tosyl-L-phenylalanine chloromethyl ketone; z-AAD.cmk, benzyloxycarbonyl-ala-Ala-Asp(Ome)-cmk; z-ARR.AFC, benzyloxycarbonyl-Ala-Arg-Arg-AFC; Ac-DEVD.AMC, acetyl-Asp-Glu-Val-Asp-AMC; z-FA.fmk, benzyloxycarbonyl-Phe-Ala-fmk; z-VAD.fmk, benzyloxycarbonyl-Val-Ala-Asp(OMe)-fmk
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Present address: Devgen N.V., Technologiepark 9 Blok DF1.60.14; B-9052 Zwijnaarde, Belgium.
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To whom correspondence should be addressed. Fax: 32-9-2645348. E-mail:[email protected].