Rapid CommunicationNeural Stem Cells in the Adult Human Brain
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Cited by (320)
Epigenetic plasticity and redox regulation of neural stem cell state and fate
2021, Free Radical Biology and MedicineCitation Excerpt :Within these niches, the NSCs are largely quiescent; only entering the cell cycle in response to mitotic stimuli (e.g. brain injuries) to generate transit amplifying cells that would subsequently differentiate into neurons, astrocytes and oligodendrocytes (Fig. 1). While the presence of NSCs and their key role in adult neurogenesis are well-documented in rodents, the existence of NSCs in the adult human brain remains controversial in part due to differences in the preparation and immunostaining procedures of brain tissues across laboratories [3–7]. Nonetheless, the observations that adult neurogenesis is impaired in mouse models of neurodegenerative diseases, including Alzheimer's disease (AD) [8] and Parkinson's disease [9], have strengthened the physiological relevance of NSCs in maintaining brain health over the lifespan of an organism.
Adult Hippocampal Neurogenesis in Aging and Alzheimer's Disease
2021, Stem Cell ReportsNeurogenesis in the adult hypothalamus: A distinct form of structural plasticity involved in metabolic and circadian regulation, with potential relevance for human pathophysiology
2021, Handbook of Clinical NeurologyCitation Excerpt :This approach requires highly specialized infrastructure and protocols and is currently mastered by only one laboratory, but would be highly informative to explore also the adult human hypothalamic niche, provided that this region harbors sufficient levels of neurogenesis to be detected by this technique. Another widely used procedure to evaluate whether a brain region contains NSCs is the neurosphere assay, which probes in vitro the two cardinal properties of stem cells, i.e., self-renewal and multipotency, and has helped support neurogenesis in the SVZ and hippocampus of adult human subjects, even in old age (Johansson et al., 1999; Kukekov et al., 1999; Sanai et al., 2004; Hermann et al., 2006; Leonard et al., 2009). Most of these studies used intraoperative tissue specimens, which can be obtained relatively easily given the frequency of patients undergoing surgery for epilepsy, tumor, or vascular anomalies.
A role for CXC chemokines and their receptors in stress axis regulation of common carp
2019, General and Comparative EndocrinologyNeural stem cell heterogeneity in the mammalian forebrain
2018, Progress in Neurobiology
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