Regular ArticleInduction of EGF-Dependent Apoptosis by Vacuolar-Type H+-ATPase Inhibitors in A431 Cells Overexpressing the EGF Receptor
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2014, Pesticide Biochemistry and PhysiologyCitation Excerpt :In nematodes, the V-ATPase seems to have a key role in nematode biology, mainly in nematode cuticle synthesis, nutrition, osmoregulation and reproduction [10,11]. N-ethylmaleimide dicyclohexylcarbodiimide and omeprazole are unspecific inhibitors of V-ATPase, causing molecular interference inhibition at low micromolar concentrations [12–15], while antibiotics such us bafilomycin and concanamycins A-F macrocyclic lactones, archazolid and apicularen are potent and specific inhibitors acting at nanomolar levels [16–18]. In the present study, we firstly used a cellular approach to demonstrate a critical requirement for lactones in V-ATPase function known to be involved in different aspects of the homeostasis.
Destruxins: Fungal-derived cyclohexadepsipeptides with multifaceted anticancer and antiangiogenic activities
2013, Biochemical PharmacologyCitation Excerpt :To gain more insights into their mode of action, in the here presented study it was shown that Dtx induce apoptotic cell death mainly via the intrinsic pathway in HCT116 cells. Previously, for Dtx E caspase-dependent apoptosis induction was reported in EGF-stimulated human epidermal carcinoma A431 cells while in unstimulated A431 cells Dtx E induced growth arrest [43]. Moreover, our data suggest Dtx-mediated inhibition of the phosphoinositide 3-kinase/Akt pathway indicated by decreased phosphorylation (activation) of Akt and its downstream targets ribosomal protein S6 accompanied by down-regulation of cyclin D1, the latter is associated with apoptosis and additionally cell cycle arrest [44].
Development and applications of destruxins: A review
2012, Biotechnology AdvancesCitation Excerpt :Within the following sections, special attention is given to M. anisopliae, one of the most famous entomopathogenic fungi, known for its use as a bioinsecticide (Ghanbary et al., 2009; Hussain et al., 2011; Kanga et al., 2010; Maniania et al., 2002; Sowjanya Sree et al., 2008; Tavassoli et al., 2011). The secondary metabolites isolated from the culture mycelium of M. anisopliae also have antitumor activities (Kobayashi et al., 2004; Yoshimoto and Imoto, 2002). As the result of its biotechnological potential, there has been a significant interest in developing processes for the cultivation of M. anisopliae in bioreactors to produce more dtxs for these applications.
Coronatin-1 isolated from entomopathogenic fungus Conidiobolus coronatus kills Galleria mellonella hemocytes in vitro and forms potassium channels in planar lipid membrane
2011, ToxiconCitation Excerpt :What’s more, G. mellonella plasmatocytes isolated from larvae infected with M. anisopliae as well as those in vitro treated with destruxins, exhibited symptoms of apoptosis: swollen nuclei, clumped chromatin, and blebs on the cell membrane (Vilcinskas and Götz, 1999). Destruxins also show numerous biological activities against non-insects including induction of apoptosis in human tumor cells and osteoclasts (Yoshimoto and Imoto, 2002; Lang, 2010). In some contrast, in vitro assays with beauverolide L and cyclosporin A indicated no adverse effects of these mycotoxins on attachment or spreading of isolated G. mellonella plasmatocytes; however dose-dependent inhibition of their phagocytic activity was accompanied by cytoskeleton alterations that differed from those observed in plasmatocytes from infected G. mellonella larvae or reported from other fungal secondary metabolites (Vilcinskas et al., 1999).
CD95 activation in the liver: Ion fluxes and oxidative signaling
2007, Archives of Biochemistry and BiophysicsCitation Excerpt :EGFR activation was shown in response to deoxycholic acid and taurodeoxycholate [91,94], resulting in the stimulation of the Ras/Raf/Erk pathway, which may counteract the proapoptotic action of these bile salts [95]. Whereas EGFR activation can protect from apoptosis in some epithelial cell lines [91,95], EGF was recently reported to augment CD95-mediated apoptosis in endometrial epithelial cells [96] and human epidermal carcinoma A431 cells [97]. However, in hepatocytes and in the intact rat liver, EGFR activation in response to hydrophobic bile salts is a prerequisite for apoptosis induction [26].
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