Regular ArticlePhotoreceptor Degeneration in Vitamin A Deprivation and Retinitis Pigmentosa: the Equivalent Light Hypothesis
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Losing, preserving, and restoring vision from neurodegeneration in the eye
2023, Current BiologyRegulation of calcium homeostasis in the outer segments of rod and cone photoreceptors
2018, Progress in Retinal and Eye ResearchStructural and molecular bases of rod photoreceptor morphogenesis and disease
2016, Progress in Retinal and Eye ResearchBifurcation analysis of a photoreceptor interaction model for Retinitis Pigmentosa
2016, Communications in Nonlinear Science and Numerical SimulationCitation Excerpt :Unfortunately, patients typically come to the doctor and are diagnosed with RP once their daylight vision is beginning to be lost, which is often far into the disease progression. While numerous therapies exist that can slow the progression of RP, there is no cure for it [9,10,12,13,15,23,24,26,28]. The photoreceptors (rods and cones) are the most metabolically active cells in the body.
Kinetic, energetic, and mechanical differences between dark-state rhodopsin and opsin
2013, StructureCitation Excerpt :This covalently bound 11-cis-retinal is an inverse agonist that locks the GPCR in the inactive dark state. In the absence of the chromophore, the apoprotein opsin exhibits a low level of constitutive activity (Melia et al., 1997), which causes retinal degeneration in Leber congenital amaurosis or vitamin A deficiency (Fain and Lisman, 1993; Woodruff et al., 2003). A recent crystal structure of opsin reveals that the transmembrane region undergoes significant α-helical rearrangements compared to dark-state rhodopsin (Okada et al., 2004; Palczewski et al., 2000; Park et al., 2008).
Tracing the progression of retinitis pigmentosa via photoreceptor interactions
2013, Journal of Theoretical BiologyCitation Excerpt :RP is the term used to describe a collection of inherited degenerative eye diseases, which are not fully understood and for which reliable long term treatments still await (Shintani et al., 2009; Phelan and Bok, 2000; Mohand-Said et al., 2001; Hamel, 2006; Mohand-Said, 2000; Murakami et al., 2008). While the vast majority of mutations have been identified in the genes that affect the rods, both rods and cones ultimately are affected (Shen et al., 2005; Busskamp et al., 2010; Phelan and Bok, 2000; Mohand-Saïd et al., 1998; Fain and Lisman, 1993; Hamel, 2006). There are numerous other degenerative eye diseases that are not termed RP but that follow similar mechanisms of cell death triggered by mutations.