Regular ArticleForelimb Motor Performance Following Dorsal Column, Dorsolateral Funiculi, or Ventrolateral Funiculi Lesions of the Cervical Spinal Cord in the Rat
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A micro-LED implant and technique for optogenetic stimulation of the rat spinal cord
2021, Experimental NeurologyCitation Excerpt :The current device is one of the few spinal implants to be designed for optogenetic stimulation in rats, with the majority of approaches targeting mice (Lu et al., 2017, 2014; Montgomery et al., 2015; Park et al., 2015; Samineni et al., 2017). Rats are the preferred animal model when complex behavioral tasks must be trained to assess recovery from injuries (Aitman et al., 2016; Alaverdashvili et al., 2008; Ellenbroek and Youn, 2016; Hirst et al., 2003; Irvine et al., 2010; Jones and Schallert, 1992; Kjell and Olson, 2016; Schrimsher and Reier, 1993; Whishaw et al., 2008). Other implants targeting rat spinal stimulation (Montgomery et al., 2015) use a laser light source similar to others designed for mice (Bonin et al., 2016; Lu et al., 2014, Lu et al., 2017).
Rat models of central nervous system injury
2019, The Laboratory RatFunctional and histopathological changes induced by intraparenchymal injection of kainic acid in the rat cervical spinal cord
2015, NeuroToxicologyCitation Excerpt :Different experimental methods have been used to study spinal cord injury (SCI) and neurodegenerative diseases. Some of the most commonly experimental models used are the weight drop (contusion) (Chvatal et al., 2008; von Euler et al., 1996), the transection of the dorsal section of the spinal cord (Kunkel-Bagden et al., 1993; Schrimsher and Reier, 1993) and the injection of a specific compound into the spinal cord (neurotoxin) (Klein et al., 2009). Thus, a reliable test protocol, suitable for the injury model is essential for proper evaluation of motor and sensory dysfunctions, as well as functional recovery after SCI.