Regular ArticleOn the Role of Enkephalin Cotransmission in the GABAergic Striatal Efferents to the Globus Pallidus
References (0)
Cited by (143)
GAT-3 Dysfunction Generates Tonic Inhibition in External Globus Pallidus Neurons in Parkinsonian Rodents
2018, Cell ReportsCitation Excerpt :Artificial elevation of GABAergic transmission by the pharmacological inhibition of GATs induces a reduction of GP neuron firing discharge in awake DA-intact monkeys (Galvan et al., 2005, 2010), which somehow mimics the hypoactivity observed in PD. On the other hand, blocking GABAA receptors in DD rodents increases GP neuron activity and produces marked antiparkinsonian effects (Maneuf et al., 1994; Xue et al., 2010). As no specific agonist or positive modulator of GAT-3 is currently available, we inhibited GAT-3 using microinjections of the selective antagonist SNAP-5114 in the GP of DA-intact rats, and we found that, while forelimb akinesia was intact, motor coordination was significantly worse compared to vehicle-injected rats.
Neuroprotection and neurorestoration as experimental therapeutics for Parkinson's disease
2017, Experimental NeurologyPsychostimulant-Induced Gene Regulation in Striatal Circuits
2016, Handbook of Behavioral Neuroscience
Copyright © 1994 Academic Press. All rights reserved.