Regular ArticleSurvival and Differentiation of Rat and Human Epidermal Growth Factor-Responsive Precursor Cells Following Grafting into the Lesioned Adult Central Nervous System
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The bioengineering of exogenic organs and/or cells for use in regenerative medicine
2018, Engineering in Medicine: Advances and ChallengesOld and new challenges in Parkinson's disease therapeutics
2017, Progress in NeurobiologyStrategies for bringing stem cell-derived dopamine neurons to the clinic—The NYSTEM trial
2017, Progress in Brain ResearchCitation Excerpt :The most likely initial choice for those efforts was NSCs with pluripotent stem cells serving as an interesting alternative. Extensive studies using NSCs or neural precursor cell (NPC) populations revealed that most available sources yield engraftable DA neurons at very low efficiencies (Ourednik et al., 2002; Svendsen et al., 1996). The reason for their limited differentiation potential is due to the highly specific progenitor population present in the midbrain that give rise to mDA neurons during mouse and human development, with unique gene expression profiles and lineage potential, as detailed in a very elegant, recent single cells transcriptome study (La Manno et al., 2016).
Fate of two types of cerebellar graft in wild type and cerebellar mutant mice
2014, Journal of Applied BiomedicineDerivation of striatal neurons from human stem cells
2012, Progress in Brain Research
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