Regular ArticleDifferentiation of Mesencephalic Progenitor Cells into Dopaminergic Neurons by Cytokines☆
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2022, Brain, Behavior, and ImmunityMicroglia-Secreted Factors Enhance Dopaminergic Differentiation of Tissue- and iPSC-Derived Human Neural Stem Cells
2021, Stem Cell ReportsCitation Excerpt :Embryonic microglia are known to secrete cytokines, including IL-1β and TNFα (Deverman and Patterson, 2009; Giulian et al., 1988; Munoz-Fernandez and Fresno, 1998), and IGF1 (Wlodarczyk et al., 2017). IL-1β is a recognized mitogen for astrocytes (Giulian et al., 1988; Wang et al., 2007) and has been found to increase astrogliogenesis while decreasing neurogenesis of hippocampal neural progenitor cells (NPCs) (Chen et al., 2013; Koo and Duman, 2008; Wang et al., 2007; Zunszain et al., 2012), but recombinant IL-1β has also been shown to enhance differentiation of mesencephalic NPCs into dopaminergic neurons (Ling et al., 1998). The IL-1β concentration detected in our conditioned co-culture medium was very low (0.5–0.8 pg/mL), but treatment of differentiating hVM1-Bcl-XL NSCs with both low and high concentrations of recombinant human IL-1β increased the yield of dopaminergic neurons.
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F. H. GageY. Christen
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