Regular ArticleThe Role of Group I and Group II Metabotropic Glutamate Receptors in Modulation of Striatal NMDA and Quinolinic Acid Toxicity
References (59)
- et al.
Selective activation of quisqualate metabotropic receptor potentiates NMDA but not AMPA responses
Eur. J. Pharmacol.
(1991) - et al.
Selective activation of group II mGluRs with LY354740 does not prevent neuronal excitotoxicity
Neuropharmacology
(1999) - et al.
Phenylglycine derivatives discriminate between mGluR1- and mGluR5-mediated responses
Neuropharmacology
(1995) - et al.
Neuroprotective activity of the potent and selective mGlu1a metabotropic glutamate receptor antagonist, (+)-2-methyl-4 carboxyphenylglycine (LY367385): Comparison with LY357366, a broader spectrum antagonist with equal affinity for mGlu1a and mGlu5 receptors
Neuropharmacology
(1999) - et al.
Protective effect of the metabotropic glutamate receptor agonist, DCG-IV, against excitotoxic neuronal death
Eur. J. Pharmacol.
(1994) - et al.
Activation of metabotropic glutamate receptors coupled to inositol phospholipid hydrolysis amplifies NMDA-induced neuronal degeneration in cultured cortical cells
Neuropharmacology
(1995) - et al.
The inhibitory mGluR agonist, S-4-carboxy-phenylglycine selectively attenuates NMDA neurotoxicity and oxygen-glucose deprivation-induced neuronal death
Neuropharmacology
(1995) - et al.
Activation of quisqualate metabotropic receptors reduces glutamate and GABA-mediated synaptic potentials in the rat striatum
Neurosci. Lett.
(1992) - et al.
Pharmacological analysis of carboxyphenylglycines at metabotropic glutamate receptors
Eur. J. Neurosci. Mol. Pharmacol. Sect.
(1994) Glutamate neurotoxicity and diseases of the nervous system
Neuron
(1988)
Excitotoxic injury of the neostriatum: A model for Huntington's disease
TINS
(RS)-2-Chloro-5-hydroxyphenylglycine (CHPG) activates mGlu(5), but not mGlu(1), receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus
Neuropharmacology
Metabotropic glutamate receptor agonists inhibit endogenous glutamate release from rat striatal synaptosomes
Eur. J. Pharmacol.
The neostriatal mosaic: Multiple levels of compartmental organization
Trends Neurosci.
Neurotransmitters and neuromodulators in the basal ganglia
Trends Neurosci.
Exitatory amino acids and Alzheimer's disease
Neurobiol. Aging
Striatal interneurones: Chemical, physiological and morphological characterization
Trends Neurosci.
Expression of group one metabotropic glutamate receptor subunit mRNAs in neurochemically identified neurons in the rat neostriatum, neocortex, and hippocampus
Brain Res. Mol. Brain Res.
Patterns of cell loss in Huntington's disease
TINS
Neurotoxicity of (2S,1′R,2′R,3′R)-2-(2,3-dicarboxycycloproply)glycine, a potent agonist for class II metabotropic glutamate receptors, in the rat
Neuroscience
Excitatory amino acid neurotoxicity and neurodegenerative diseases
Trends Pharmacol. Sci.
Quinolinate differentiates between forebrain and cerebellar NMDA receptors
Eur. J. Pharmacol.
Pre- and postsynaptic localization of a metabotropic glutamate receptor, mGluR2, in the rat brain: An immunohistochemical study with a monoclonal antibody
Neurosci. Lett.
Group-I metabotropic glutamate receptors: Hypotheses to explain their dual role in neurotoxicity and neuroprotection
Neuropharmacology
Metabotropic receptors in excitotoxicity: (S)-4-Carboxy-3-hydroxyphenylglycine ((S)-4C3HPG) protects against rat striatal quinolinic acid lesions
Neurosci. Lett.
Protection with metabotropic glutamate 1 receptor antagonists in models of ischemic neuronal death: time-course and mechanisms
Neuropharmacology
The metabotropic glutamate receptors, mGluR2 and mGluR3 show unique postsynaptic, presynaptic and glial localizations
Neuroscience
Neurotransmitter receptors. I. The metabotropic glutamate receptors: Structure and functions
Neuropharmacology
Selective inhibition of forskolin-stimulated cyclic AMP formation in rat hippocampus by a novel mGluR agonist, 2R,4R-4-aminopyrrolidine-2,4-dicarboxylate
Neuropharmacology
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2018, Progress in NeurobiologyCitation Excerpt :Among the BG, the globus pallidus has the lowest NMDAR density (Ozawa et al., 1998), but suffers from glutamate-induced toxicity because of the high density of postsynaptic metabotropic mGluR1 receptor (Martin et al., 1992). Group I mGluRs have a predominant role in excitotoxicity compared to group II mGluRs (Orlando et al., 2001), and the high expression of mGluR1 among MSNs participates in MSNs peculiar vulnerability to excitotoxic insults (Testa et al., 1998). Indeed, mGluR1 promote calcium inward currents even in absence of NMDAR stimulus, promoting a backdoor pathway to reach excitotoxicity which is independent from the activation of the synapse (Bernal et al., 2000; Giribaldi et al., 2013).
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