Regular ArticlePDGF-α Receptor and Myelin Basic Protein mRNAs Are Not Coexpressed by Oligodendrocytesin Vivo:A Doublein SituHybridization Study in the Anterior Medullary Velum of the Neonatal Rat
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The Healthy and Diseased Microenvironments Regulate Oligodendrocyte Properties: Implications for Regenerative Medicine
2018, American Journal of PathologyCitation Excerpt :Of the PDGF family, PDGF-AA is most known for its functions in OL development. PDGF-AA binds to the PDGFα receptor that is expressed by many OL progenitors.91 Mice lacking PDGFα receptors demonstrate defects in OL progenitor proliferation and migration and show precocious OL differentiation and myelination.92,93
Oligodendrocyte progenitor cells are paired with GABA neurons in the mouse dorsal cortex: Unbiased stereological analysis
2017, NeuroscienceCitation Excerpt :These estimates suggest that the stereological parameters chosen were appropriate (Gundersen et al., 1999). PDGFRα is selectively expressed by OPCs (Nishiyama et al., 1996; Butt et al., 1997). To determine the total number of OPCs in the dorsal portion of the cerebral cortex of adult mice, we looked at the estimated total number of PDGFRα+ cells located between lateral 0.36 mm and lateral 2.52 mm in those regions.
Unbiased stereological analysis of the fate of oligodendrocyte progenitor cells in the adult mouse brain and effect of reference memory training
2017, Behavioural Brain ResearchCitation Excerpt :Oligodendrocyte progenitor cells (OPCs; also known as NG2-glial cells, synantocytes, or polydendrocytes) are a type of glial cell that give rise, as their name suggests, to myelinating oligodendrocytes during early stages of post-natal life [1,2]. OPCs specifically express the platelet-derived growth factor receptor alpha (PDGFRα) and the chondroitin sulfate proteoglycan neuron-glia antigen 2 (NG2), both of which are downregulated in favor of O4 and myelin-specific antigens as the cell transitions from an OPC to an oligodendrocyte phenotype [3–6]. Interestingly, a large number of OPCs remain undifferentiated after developmental myelination is completed, and OPCs correspond to 2–9% of the total cell population of the adult brain [7–11].
Dysfunction of platelet-derived growth factor receptor α (PDGFRα) represses the production of oligodendrocytes from arylsulfatase A-deficient multipotential neural precursor cells
2015, Journal of Biological ChemistryCitation Excerpt :Because the PDGFRα is a critical signal for the generation of OPCs and their timely maturation into OLs, we studied its expression in ASA−/− NPs. PDGFRα is crucial for regulating the number and survival of OPCs/OL during myelination (9–11, 39–41), mainly by regulating the activity of the AKT or ERK1/2 pathway (42–44). To determine whether this receptor was involved in the phenotype of ASA−/− cells, various experiments were performed.
Expression of mutant human DISC1 in mice supports abnormalities in differentiation of oligodendrocytes
2011, Schizophrenia ResearchOligodendrocyte morphology
2009, Encyclopedia of Neuroscience