Regular ArticleAnalysis of Interactions of the Adhesion Molecule TAG-1 and Its Domains with Other Immunoglobulin Superfamily Members
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Immunoglobulin cell adhesion molecules of the Ig-FNIII type and neurodevelopment
2021, Factors Affecting Neurodevelopment: Genetics, Neurology, Behavior, and DietDistinct roles for the cell adhesion molecule Contactin2 in the development and function of neural circuits in zebrafish
2018, Mechanisms of DevelopmentCitation Excerpt :Membrane proteins playing important roles in neurodevelopment include the cell adhesion molecules of the immunoglobulin superfamily (IgSF-CAMs), which are anchored to the membrane by a glycosylphosphatidyl inositol (GPI) linkage or a single transmembrane domain, have varying numbers of Ig-like extracellular domains, and are widely expressed during vertebrate neural development (Gennarini et al., 2017; Stoeckli, 2004; Stoeckli and Landmesser, 1995). Contactin2 (Cntn2)/Transient Axonal Glycoprotein 1 (Tag1), a GPI-linked IgSF-CAM, has six Ig-like domains and four fibronectin domains (Furley et al., 1990), and can bind homophilically (Kunz et al., 1998) as well as heterophilically with other IgSF CAMs such as L1, NgCAM, and NrCAM (Buchstaller et al., 1996; Fitzli et al., 2000; Kuhn et al., 1991; Kunz et al., 1998; Pavlou et al., 2002; Suter et al., 1995). Cntn2 can also interact with contactin-associated protein-like 2 (Caspr2) at the juxtaparanode region in neurons (Tzimourakas et al., 2007).
A versatile genetic tool to study midline glia function in the Drosophila CNS
2017, Developmental BiologyCitation Excerpt :More recent studies in Drosophila embryonic CNS midline have demonstrated the requirement of Nrx IV and Wrapper in neuron-glial interactions and ensheathment of commissural axons (Stork et al., 2009; Wheeler et al., 2009; Slováková and Carmena, 2011; Jacobs, 2000; Noordermeer et al., 1998). While Wrapper does not have a direct mammalian ortholog, its structure is very similar to proteins found to interact with Nrx IV/Caspr such as Cont/TAG1 (Pavlou et al., 2002). Both Wrapper and Cont are Ig-superfamily proteins with Ig/FNIII domains and are inserted in the membrane via their GPI anchors.
L1CAM: Cell adhesion and more
2016, Progress in Histochemistry and CytochemistryCitation Excerpt :The Ig-like domains are also involved in a number of heterophilic interactions. The binding partners include Ig superfamily proteins NCAM, TAG-1/axonin, F11/contactin [69,66,62]. Binding of the highly glycosylated mucin type glycoprotein CD24 depends on its modification with α2,3-sialic acid, and this interaction occurs in trans between CD24 and L1CAM at the surface of neurite outgrowth-competent cells [50].
Significance of F3/Contactin gene expression in cerebral cortex and nigrostriatal development
2012, Molecular and Cellular NeuroscienceCitation Excerpt :Besides that in axonal growth and pathfìnding control, axonal adhesive glycoproteins may play relevant roles in further aspects of neural development, including precursor proliferation and migration (Bizzoca et al., 2003; Lu et al., 2008; Maness and Schachner, 2007; Traka et al., 2003), synaptic contact formation and myelination (Laursen et al., 2009; Zhang et al., 2008). The involvement of such molecules in a wide set of developmental events implies that the underlying genes are tightly and coordinately regulated at the cellular levels within distinct developmental steps, which may be relevant for their functional cooperation (Bizzoca et al., 2003; Buttiglione et al., 1998; Charles et al., 2002; Hortsch et al., 2009; Pavlou et al., 2002; Pesheva et al., 2006). Among the axonally-expressed glycoproteins, F3/Contactin deserves a special mention.