Regular ArticleMicrovessel Organization and Structure in Experimental Brain Tumors: Microvessel Populations with Distinctive Structural and Functional Properties
References (89)
- et al.
The vasculature of experimental brain tumours. Part 2. A quantitative assessment of morphological abnormalities
J. Neuropathol. Exp. Neurol.
(1981) - et al.
Methods for quantifying the transport of drugs across brain barrier systems
Pharmacol. Therapeut.
(1981) - et al.
Rational brain tumor chemotherapy: the interaction of drug and tumor
- et al.
The closest-individual method in the analysis of the distribution of capillaries
Microvasc. Res.
(1982) - et al.
Cerebral capillary bed structure of normotensive and chronically hypertensive rats
Microvasc. Res.
(1990) The diaphragm of capillary endothelial fenestrations
J. Ultrastruct. Res.
(1962)- et al.
New delivery systems for brain tumor therapy
Neurol. Clin.
(1995) The role of chemotherapy in the treatment of gliomas in adults
Cancer Treat. Rev.
(1989)- et al.
Microvascular abnormalities in virally-induced canine brain tumors: Structural bases for altered blood-brain barrier function
J. Neurol. Sci.
(1972) - et al.
A three-dimensional junction-pore-matrix model for capillary permeability
Microvasc. Res.
(1992)
Quantitative analysis of microvascular changes in diffuse astrocytic neoplasms with increasing grade of malignancy
Hum. Pathol.
Three-dimensional reconstruction of brain capillaries from frozen serial sections
Microvasc. Res.
The RG2 rat glioma model
J. Neurooncol.
Microvessel density in brain tumors
Anticancer Res.
Migration and proliferation of endothelial cells in preformed and newly formed blood vessels during tumor angiogenesis
Microvasc. Res.
Tumor angiogenesis as a prognostic assay for invasive ductal breast carcinoma
J. Natl. Cancer Inst.
Differential permeability and quantitative MR imaging of a human lung carcinoma brain xenograft in the nude rat
Am. J. Pathol.
Rat brain tumor models in experimental neuro-oncology: The 9l, C6, T9, F98, RG-2 (D74), RT-2 and CNS1 gliomas
J. Neurooncol.
Endothelial fenestral diaphragms: A quick-freeze, deep-etch study
J. Cell Biol.
Monoclonal antibody 81C6 distribution, permeability and cellular proliferation in human glioma brain xenografts: a triple label autoradiographic study
Proc. Am. Assoc. Cancer Res.
Heterogeneity of genotypic and phenotypic characteristics of fifteen permanent cell lines derived from human gliomas
J. Neuropathol. Exp. Neurol.
Chemotherapy of brain tumors: Physiological and pharmacokinetic considerations
Semin. Oncol.
Regional blood flow in ethylnitrosourea (ENU)-induced brain tumors
Ann. Neurol.
Regional blood-to-tissue transport in ethylnitrosourea (ENU)-induced brain tumors
Ann. Neurol.
Regional localization of a glioma associated antigen defined by monoclonal antibody 81C6: Implications for diagnosis and therapy
Cancer Res.
The transport of alpha-aminoisobutyric acid across brain capillary and cellular membranes
J. Cereb. Blood Flow Metab.
A quantitative assessment of microvessel ultrastructure in C6 astrocytoma spheroids transplanted to brain and to muscle
J. Neuropathol. Exp. Neurol.
The permeability of capillaries in various organs as determined by the use of the “indicator diffusion” method
Acta Physiol. Scand.
Quantitation and physiological characterization of angiogenic vessels in mice: Effect of basic fibroblast growth factor, vascular endothelial growth factor/vascular permeability factor, and host microenvironment
Am. J. Pathol.
Do anticancer agents reach the tumor target in the human brain
Canc. Chemother. Pharmacol.
Structural, ultrastructural, and functional correlations among local capillary systems with the brain
Practical Methods in Electron Microscopy
Permeability of different brain tumor models to horseradish peroxidase
J. Neuropathol. Exp. Neurol.
Regional measurements of blood-to-tissue transport in transplanted RG-2 rat gliomas
Cancer Res.
Regional blood flow and blood-to-tissue transport in five brain tumor models: Implications for chemotherapy
Regional measurements of blood flow in transplanted RG-2 rat gliomas
Cancer Res.
Quantitative measurements of capillary transport in human brain tumors by computed tomography
Ann. Neurol.
Topography of capillary density, glucose metabolism, and microvascular function within the rat inferior colliculus
J. Cereb. Blood Flow Metab.
Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment
Proc. Natl. Acad. Sci. USA
Transport of molecules across tumor vasculature
Canc. Metas. Rev.
Vascular and interstitial barriers to delivery of therapeutic agents in tumors
Canc. Metas. Rev.
Barriers to drug delivery in solid tumors
Sci. Am.
Delivery of molecular medicine to solid tumors
Science
The next frontier of molecular medicine: Delivery of therapeutics
Nat. Med.
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2022, European Journal of Pharmaceutics and BiopharmaceuticsCitation Excerpt :About 80% of this volume is occupied with brain cells and 20% is the extracellular space. The vasculature system that is responsible for the transport of O2, essential nutrients and drugs to the brain takes about 3% of the brain volume and yet, the inter-capillary distance is about 10–40 μm [1-4]. In other words, the brain is highly vascularised with a network of 600 km small capillaries supplying metabolic requirements for brain function.
- 1
Present address: Department of Neurosurgery, National Institutes of Health, Bethesda, MD 20892.
- 2
Present address: Hungarian–Japanese EM Center, University Medical School of Debrecen, P.O. Box 23, H-4014 Debrecen, Hungary.
- 3
To whom correspondence and reprint requests should be addressed at Division of Neurology, Evanston Hospital, 2650 Ridge Avenue, Evanston, IL 60201. Fax: 847/570-1934. E-mail: [email protected].