Elsevier

NeuroImage

Volume 11, Issue 5, May 2000, Pages 380-391
NeuroImage

Regular Article
Distinguishing the Functional Roles of Multiple Regions in Distributed Neural Systems for Visual Working Memory

https://doi.org/10.1006/nimg.2000.0592Get rights and content

Abstract

We have investigated the human neural systems for visual working memory using functional magnetic resonance imaging to distinguish sustained activity during memory delays from transient responses related to perceptual and motor operations. These studies have identified six distinct frontal regions that demonstrate sustained activity during memory delays. These regions could be distinguished from brain regions in extrastriate cortex that participate more in perception and from brain regions in medial and lateral frontal cortex that participate more in motor control. Moreover, the working memory regions could be distinguished from each other based on the relative strength of their participation in spatial and face working memory and on the relative strength of sustained activity during memory delays versus transient activity related to stimulus presentation. These results demonstrate that visual working memory performance involves the concerted activity of multiple regions in a widely distributed system. Distinctions between functions, such as perception versus memory maintenance, or spatial versus face working memory, are a matter of the degree of participation of different regions, not the discrete parcellation of different functions to different modules.

References (36)

  • J.A. Fiez et al.

    A positron emission tomography study of the short-term maintenance of verbal information

    J. Neurosci.

    (1996)
  • S. Funahashi et al.

    Mnemonic coding of visual space in the monkey’s dorsolateral prefrontal cortex

    J. Neurophysiol.

    (1989)
  • J.M. Fuster

    Behavioral electrophysiology of the prefrontal cortex of the primate

  • P.S. Goldman-Rakic

    Cellular and circuit basis of working memory in prefrontal cortex of nonhuman primates

  • J.V. Haxby et al.

    Hemispheric differences in neural systems for face working memory: A PET–rCBF study

    Hum. Brain Mapp.

    (1995)
  • J.V. Haxby et al.

    Multiple regression analysis of effects of interest in fMRI time series

  • A. Ishai et al.

    Distributed representation of objects in the human ventral visual pathway

    Proc. Natl. Acad. Sci. USA

    (1999)
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    This article was first published in Volume 11, Number 2, pages 98–110, and is reprinted here for the reader's convenience and for the continuity of this special issue.

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