Regular ArticleSphingomyelinases in cell regulation
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Fructose aggravates copper-deficiency-induced non-alcoholic fatty liver disease
2023, Journal of Nutritional BiochemistryTargeted lipidomics reveal derangement of ceramides in major depression and bipolar disorder
2019, Metabolism: Clinical and ExperimentalCitation Excerpt :The latter revealed that the abundance of SMPD1 (gene encoding acidic sphingomyelinase, ASM) splice variants, which encode for enzymatically low-active “protective” ASM variants were rarely found in MD patients [54]. In line with this conclusion, a number of antidepressants and antipsychotic agents are functional inhibitors of ASM, called FIASM [53,55], which converts sphingomyelin to ceramides at the inner lysosomal membrane and plasma membrane, hence contributing to sphingomyelin degradation and ceramide production in the lysosome [15,56]. Although loss of function mutations of ASM in Niemann-Pick disease are obviously detrimental and lead to a lysosomal storage disease [57], it has been proposed that moderate or transient inhibition of ASM is of therapeutic value for a number of diseases including major depression [53] and cancer [58,59].
Brain metabolic dysfunction at the core of Alzheimer's disease
2014, Biochemical PharmacologyCitation Excerpt :Ceramides accumulate in cells due to disturbances in sphingolipid metabolism [67,199–201] and upregulation of pro-ceramide genes [110,202]. Altered sphingolipid metabolism aberrantly increases intracellular ceramide levels and insulin resistance [113,136,199,200,203–205] in obesity, T2DM, NASH, and AD [81,82,146,190–196]. Since none of the experimental models of peripheral insulin resistance were associated with substantial alterations ceramide-related gene expression or enzymatic activity in brain, if toxic ceramides were to mediate disease, they must originate from sources outside of the CNS.
Ablation of neuronal ceramide synthase 1 in mice decreases ganglioside levels and expression of myelin-associated glycoprotein in oligodendrocytes
2012, Journal of Biological ChemistryModulation of Hepatic Apoptotic Pathways by Dietary Olive and Sunflower Oil
2010, Olives and Olive Oil in Health and Disease Prevention