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Reviews of Physiology, Biochemistry and Pharmacology 166 pp 1–22Cite as

TRP Channels Coordinate Ion Signalling in Astroglia

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Part of the book series: Reviews of Physiology, Biochemistry and Pharmacology ((REVIEWS,volume 166))

Abstract

Astroglial excitability is based on highly spatio-temporally coordinated fluctuations of intracellular ion concentrations, among which changes in Ca2+ and Na+ take the leading role. Intracellular signals mediated by Ca2+ and Na+ target numerous molecular cascades that control gene expression, energy production and numerous homeostatic functions of astrocytes. Initiation of Ca2+ and Na+ signals relies upon plasmalemmal and intracellular channels that allow fluxes of respective ions down their concentration gradients. Astrocytes express several types of TRP channels of which TRPA1 channels are linked to regulation of functional expression of GABA transporters, whereas TRPV4 channels are activated following osmotic challenges and are up-regulated in ischaemic conditions. Astrocytes also ubiquitously express several isoforms of TRPC channels of which heteromers assembled from TRPC1, 4 and/or 5 subunits that likely act as stretch-activated channels and are linked to store-operated Ca2+ entry. The TRPC channels mediate large Na+ fluxes that are associated with the endoplasmic reticulum Ca2+ signalling machinery and hence coordinate Na+ and Ca2+ signalling in astroglia.

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Acknowledgements

Authors’ research was supported by Alzheimer’s Research Trust (UK) Programme Grant (ART/PG2004A/1) to A.V. and by National Science Foundation (CBET 0943343) grant to V.P. R.C.R. was additionally funded by UCSF Neuroscience and Schizophrenia T32 (MH 089920).

Conflict of Interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Faculty of Life Sciences, The University of Manchester, Oxford Road, Manchester, M13 9PT, UK

    Alexei Verkhratsky

  2. Achucarro Center for Neuroscience, IKERBASQUE, Basque Foundation for Science, Bilbao, 48011, Spain

    Alexei Verkhratsky

  3. Department of Neurobiology, Center for Glial Biology in Medicine, Atomic Force Microscopy & Nanotechnology Laboratories, Civitan International Research Center, Evelyn F. McKnight Brain Institute, University of Alabama at Birmingham, 1719 6th Avenue South, CIRC 429, Birmingham, AL, 35294, USA

    Reno C. Reyes & Vladimir Parpura

  4. Department of Psychiatry, Langley Porter Psychiatric Institute, University of California San Francisco, 401 Parnassus Avenue, San Francisco, CA, 94143, USA

    Reno C. Reyes

  5. Department of Biotechnology, University or Rijeka, Rijeka, 51000, Croatia

    Vladimir Parpura

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  1. Alexei Verkhratsky
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  2. Reno C. Reyes
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  3. Vladimir Parpura
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Correspondence to Alexei Verkhratsky or Vladimir Parpura .

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Editors and Affiliations

  1. Dept. of Cell. and Molecular Medicine Laboratory of Ion Channel Research, KU Leuven, Herestraat 49 Campus Gasthuisberg O&N, B-3000, Leuven, Belgium

    Bernd Nilius

  2. Medizinische Fakultät Walther-Straub-Institut für Pharmakologi, Ludwig-Maximilians-Universität München, München, Germany

    Thomas Gudermann

  3. Max-Planck-Institute for Biophysical Chemistry, Göttingen, Germany

    Reinhard Jahn

  4. Inst. Zytobiologie und Zytopathologie, University of Marburg, Marburg, Germany

    Roland Lill

  5. Max-Planck-Institut für Herzund Lungen, Abteilung II, Bad Nauheim, Germany

    Stefan Offermanns

  6. School of Biosciences, Cardiff University, Museum Avenue, Cardiff, UK

    Ole H. Petersen

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Verkhratsky, A., Reyes, R.C., Parpura, V. (2013). TRP Channels Coordinate Ion Signalling in Astroglia. In: Nilius, B., Gudermann, T., Jahn, R., Lill, R., Offermanns, S., Petersen, O.H. (eds) Reviews of Physiology, Biochemistry and Pharmacology 166. Reviews of Physiology, Biochemistry and Pharmacology, vol 166. Springer, Cham. https://doi.org/10.1007/112_2013_15

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