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Translational Clinical Neuroscience Perspectives on the Cognitive and Neurobiological Mechanisms Underlying Alcohol-Related Aggression

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Neuroscience of Aggression

Part of the book series: Current Topics in Behavioral Neurosciences ((CTBN,volume 17))

Abstract

Alcohol-related violence, a longstanding, serious, and pervasive social problem, has provided researchers from diverse disciplines with a model to study individual differences in aggressive and violent behavior. Of course, not all alcohol consumers will become aggressive after drinking and similarly, not all individuals with alcohol use disorders will exhibit such untoward behavior. Rather, the relationship is best conceptualized as complex and indirect and is influenced by a constellation of social, cognitive, and biological factors that differ greatly from one person to the next. Animal experiments and human studies have elucidated how these mechanisms and processes explain (i.e., mediate) the relation between acute and chronic alcohol consumption and aggressive behavior. Further, the rich body of literature on alcohol-related aggression has allowed for identification of several potential high-yield targets for clinical intervention, e.g., cognitive training for executive dysfunction; psychopharmacology targeting affect and threat perception, which may also generalize to other psychiatric conditions characterized by aggressive behavior. Here we aim to integrate pertinent findings, derived from different methodological approaches and theoretical models, which explain heterogeneity in aggressive responses to alcohol. A translational platform is provided, highlighting common factors linking alcohol and aggression that warrant further, interdisciplinary study in order to reduce the devastating social impact of this phenomenon.

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Acknowledgments

Support for this project was provided in part by VA Health Services Research and Development Funds for Dr. Adrienne Heinz.This work was also supported by the German Research Foundation (DFG: grants DFG FOR 16/17, HE 2597/14-1; Excellence Cluster EXC 257) and by the Bundesministerium für Bildung und Forschung (grants 01GQ0411 and 01QG87164 and Nationales Genomforschungsnetz grant 01 GS 08 159) for Prof. Andreas Heinz.

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  1. Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany

    Anne Beck & Andreas Heinz

  2. Center for Health Care Evaluation, VA Palo Alto Health Care System and Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Menlo Park, CA, USA

    Adrienne J. Heinz

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  1. Anne Beck
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Correspondence to Andreas Heinz .

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  1. Moses Hunt Professor of Psychology, Psychiatry, Pharmacol & Neurosci, Tufts University, Medford, Massachusetts, USA

    Klaus A. Miczek

  2. Dept of Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany

    Andreas Meyer-Lindenberg

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Beck, A., Heinz, A.J., Heinz, A. (2013). Translational Clinical Neuroscience Perspectives on the Cognitive and Neurobiological Mechanisms Underlying Alcohol-Related Aggression. In: Miczek, K., Meyer-Lindenberg, A. (eds) Neuroscience of Aggression. Current Topics in Behavioral Neurosciences, vol 17. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7854_2013_258

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