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Semaphorins: Receptor and Intracellular Signaling Mechanisms pp 61–72Cite as

Modulation of Semaphorin Signaling by Ig Superfamily Cell Adhesion Molecules

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 600))

Abstract

During axon navigation, growth cones continuously interact with molecular cues in their environment, some of which control adherence and bundle assembly, others axon elongation and direction. Growth cone responses to these different environmental cues are tightly coordinated during the development of neuronal projections. Several recent studies show that axon sensitivity to guidance cues is modulated by extracellular and intracellular signals. This regulation may enable different classes of cues to combine their effects and may also represent important means for diversifying pathway choices and for compensating for the limited number of guidance cues. This chapter focuses on the modulation exerted by Ig Superfamily cell adhesion molecules (IgSFCAMs) on guidance cues of the class III secreted semaphorins

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Author information

Authors and Affiliations

  1. Centre de Génétique Moléculaire et Cellulaire (CGMC) UMR CNRS 5534, Université Claude Bernard, Lyon1, Campus de la Doua, Bâtiment Mendel 741, 43 Bd du 11 Novembre 1918, 69622, Villeurbanne cedex, France

    Valérie Castellani

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  1. Ahmad Bechara
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  2. Julien Falk
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  3. Frédéric Moret
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  4. Valérie Castellani
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Editors and Affiliations

  1. Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands

    R. J. Pasterkamp

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Bechara, A., Falk, J., Moret, F., Castellani, V. (2007). Modulation of Semaphorin Signaling by Ig Superfamily Cell Adhesion Molecules. In: Pasterkamp, R.J. (eds) Semaphorins: Receptor and Intracellular Signaling Mechanisms. Advances in Experimental Medicine and Biology, vol 600. Springer, New York, NY. https://doi.org/10.1007/978-0-387-70956-7_6

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