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Structure and Function of the Neural Cell Adhesion Molecule NCAM pp 299–317Cite as

NCAM in Neuropsychiatric and Neurodegenerative Disorders

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 663))

Abstract

The neural cell adhesion molecule (NCAM) has roles in normal brain development, including axonal/dendritic growth and branching and synaptic plasticity. A growing body of evidence has implicated NCAM as a susceptible risk for neuropsychiatric disorders such as schizophrenia, bipolar disorder, depression, and anxiety disorder, as well as the most prevalent neurodegenerative disease, Alzheimer’s disease. While individuals with these diseases vary in symptoms, age of onset, treatment, and neuronal systems affected, they share cognitive dysfunction as a core feature. This review will highlight the evidence for NCAM in the cause or progression of each of these disorders.

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Acknowledgments

This work was supported by the UNC Schizophrenia Research Center, an NIMH Silvio O. Conte Center for the Neuroscience of Mental Disorders, (NIH grant MH064065 P.F.M.).

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Authors and Affiliations

  1. Department of Biochemistry and Biophysics, University of North Carolina, CB#7260, 505 Mary Ellen Jones Building, Chapel Hill, NC, 27599, USA

    Patricia F. Maness

  2. Silvio Conte Center for Schizophrenia Research, University of North Carolina, Chapel Hill, NC, 27599, USA

    Patricia F. Maness

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  1. Leann H. Brennaman
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  2. Patricia F. Maness
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Correspondence to Patricia F. Maness .

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  1. Panum Institute, Dept. Regenerative Medicine, University of Copenhagen, Blegdamsvej 3C, Koebenhavn N, 2200, Denmark

    Vladimir Berezin

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Brennaman, L.H., Maness, P.F. (2010). NCAM in Neuropsychiatric and Neurodegenerative Disorders. In: Berezin, V. (eds) Structure and Function of the Neural Cell Adhesion Molecule NCAM. Advances in Experimental Medicine and Biology, vol 663. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1170-4_19

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