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Neurotrophic Factors pp 67–100Cite as

Neurotrophins: Transcription and Translation

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 220))

Abstract

Neurotrophins are powerful molecules. Small quantities of these secreted proteins exert robust effects on neuronal survival, synapse stabilization, and synaptic function. Key functions of the neurotrophins rely on these proteins being expressed at the right time and in the right place. This is especially true for BDNF, stimulus-inducible expression of which serves as an essential step in the transduction of a broad variety of extracellular stimuli into neuronal plasticity of physiologically relevant brain regions. Here we review the transcriptional and translational mechanisms that control neurotrophin expression with a particular focus on the activity-dependent regulation of BDNF.

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Authors and Affiliations

  1. Department of Neurobiology, Duke University Medical Center, Durham, NC, 27710, USA

    A. E. West

  2. Institute of Gene Technology, Tallinn University of Technology, 12618, Tallinn, Estonia

    P. Pruunsild & T. Timmusk

  3. Department of Neurobiology, Interdisciplinary Center for Neurosciences, University of Heidelberg, 69120, Heidelberg, Germany

    P. Pruunsild

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  1. Department of Neuroscience, Max-Delbrück-Center for Molecular Medicine, Berlin, Germany

    Gary R. Lewin

  2. Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, USA

    Bruce D. Carter

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West, A.E., Pruunsild, P., Timmusk, T. (2014). Neurotrophins: Transcription and Translation. In: Lewin, G., Carter, B. (eds) Neurotrophic Factors. Handbook of Experimental Pharmacology, vol 220. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-45106-5_4

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