Abstract
Hypoxia inducible factor 1(HIF-1α) is the regulator of oxygen homeostasis in tissue correlated with neuroglobin (NGB) a member of the family of globins in vertebrates. The present study investigates, the expression and the location of NGB, HIF-1α in human carotid bodies, sampled at autopsy from children (mean age: 2 year ±), young (mean age: 27.5) and 4 old subjects (mean age: 73.5). The percentage of NGB positive area was higher in the old subjects (4.4 ±2.8%), as compared with the young ones (2.4 ±1.8%) and children (1.0 ±1.8%). Positive HIF-1α nuclei were detected in young and old subjects (1.0 ±0.14% vs 3.0 ±0.28%, respectively), whereas CB tissues from children did not show any HIF-1α reaction. The increase of NGB and HIF-1α expression suggests a possible role of the two oxygen sensors in the aging processes. Even though the physiological role of NGB is not well understood, it could be suggested that is act as a respiratory protein connected with HIF.
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This paper is dedicated to the memory of Prof. Sukhamay Lahiri, for his example in science and in life.
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Di Giulio, C., Zara, S., Cataldi, A., Porzionato, A., Pokorski, M., De Caro, R. (2012). Human Carotid Body HIF and NGB Expression During Human Development and Aging. In: Nurse, C., Gonzalez, C., Peers, C., Prabhakar, N. (eds) Arterial Chemoreception. Advances in Experimental Medicine and Biology, vol 758. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4584-1_36
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DOI: https://doi.org/10.1007/978-94-007-4584-1_36
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