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The role of gap junction membrane channels in secretion and hormonal action

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Abstract

Connexins, gap junctions, and coupling are obligatory features of both endocrine and exocrine glandular epithelia. Evidence from these two types of tissues, and particularly from pancreatic islets and acini, indicates that cell-to-cell communication via gap junction channels is required for proper biosynthesis, storage, and release of specific secretory products. However, endocrine and exocrine glands express a different set of connexins and show opposite connexin and coupling changes in relation with the activation and inhibition of their secretory function. Also, several hormones modulate connexin and coupling expression, and junctional coupling affects hormonal stimulation. These observations indicate that gap junction channels play an important role in the control of secretion and hormonal action.

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References

  • Atwater, I., Rosario, L., and Rojas, E. (1983).Cell Calcium 4, 451–461.

    Article  PubMed  Google Scholar 

  • Bosco, D., and Meda, P. (1992).Endocrinology 129, 3157–3166.

    Google Scholar 

  • Bosco, D., Orci, L., and Meda, P. (1989).Exp. Cell Res. 184, 72–80.

    Article  PubMed  Google Scholar 

  • Bosco, D., Soriano, J. V., Chanson, M., and Meda, P. (1994).J. Cell Physiol. 60, 378–388.

    Article  Google Scholar 

  • Chanson, M., Bruzzone, R., Bosco, D., and Meda, P. (1989).J. Cell Physiol. 139, 147–156.

    Article  PubMed  Google Scholar 

  • Chanson, M., Orci, L., and Meda, P. (1991).Am. J. Physiol. 261, G28-G36.

    PubMed  Google Scholar 

  • Eddlestone, G. T., Gonçalves, A., Bangham, J. A., and Rojas, E. (1984).J. Membr. Biol. 77, 1–14.

    Article  PubMed  Google Scholar 

  • Friend, D. S., and Gilula, N. B. (1972).J. Cell Biol. 53, 758–776.

    Article  PubMed  Google Scholar 

  • Heimberg, H., De Vos, A., Vandercammen, A., Van Schaftingen, E., Pipeleers, D., and Schuit, F. (1993).EMBO J. 12, 2873–2879.

    PubMed  Google Scholar 

  • Iwai, M., Miyashita, T., and Shimazu, T. (1995). InProgress in Cell Research, Vol. 4 (Kanno, Y. Kataoka, K., Shiba, Y., Shibata, Y., and Shimazu, T., eds.), Elsevier Science B.V., Amsterdam, pp. 297–300.

    Google Scholar 

  • Iwatsuki, N., and Petersen, O. H. (1977).Nature 268, 147–149.

    Article  PubMed  Google Scholar 

  • Iwatsuki, N., and Petersen, O. H. (1979).Pflügen Arch. Eur. J. Physiol. 380, 277–281.

    Article  Google Scholar 

  • Kanno, Y., Sasaki, Y., and Shiba, Y. (1987).Arch. Oral Biol. 32, 43–46.

    Article  PubMed  Google Scholar 

  • Kohen, E., Kohen, C., Thorell, B., Mintz, D. H., and Rabinovitch, A. (1979).Science 204, 862–865.

    PubMed  Google Scholar 

  • Kohen, E., Kohen, C., and Rabinovitch, A. (1983).Diabetes 32, 95–98.

    PubMed  Google Scholar 

  • Lawrence, T. S., Beers, W. H., and Gilula, N. B. (1978).Nature 272, 501–506.

    Article  PubMed  Google Scholar 

  • Mears, D., Sheppard, N. F., Jr., Atwater, I., and Rojas, E. (1995).J. Membr. Biol. 146, 163–176.

    PubMed  Google Scholar 

  • Meda, P. (1995). InPacemaker Activity and Intercellular Communication (Huizinga, J. D., ed.), CRC Press, Boca Raton, pp. 275–290.

    Google Scholar 

  • Meda, P., Perrelet, A., and Orci, L. (1979).J. Cell Biol. 82, 441–448.

    Article  PubMed  Google Scholar 

  • Meda, P., Amherdt, M., Perrelet, A., and Orci, L. (1981).Exp. Cell Res. 133, 421–430.

    Article  PubMed  Google Scholar 

  • Meda, P., Michaels, R. L., Halban, P. A., Orci, L., and Sheridan, J. D. (1983).Diabetes 32, 858–868.

    PubMed  Google Scholar 

  • Meda, P., Atwater, I., Gonçalves, A., Bangham, A., Orci, L., and Rojas, E. (1984a).Q. J. Exp. Physiol. 69, 719–735.

    PubMed  Google Scholar 

  • Meda, P., Perrelet, A., and Orci, L. (1984b). InModern Cell Biology, Vol. 3 (Satir B. H., ed.), Alan Liss, New York, pp. 131–196.

    Google Scholar 

  • Meda, P., Bruzzone, R., Knodel, S., and Orci, L. (1986).J. Cell Biol. 103, 475–483.

    Article  PubMed  Google Scholar 

  • Meda, P., Bruzzone, R., Chanson, M., Bosco, D., and Orci, L. (1987).Proc. Natl. Acad. Sci. USA 84, 4901–4904.

    PubMed  Google Scholar 

  • Meda, P., Bosco, D., Chanson, M., Giordano, E., Vallar, L., Wollheim, C., and Orci, L. (1990).J. Clin. Invest. 86, 759–768.

    PubMed  Google Scholar 

  • Meda, P., Chanson, M., Pepper, M., Giordano, E., Bosco, D., Traub, O., Willecke, K., El Aoumari, A., Gros, D., Beyer, E., Orci, L., and Spray, D. C. (1991).Exp. Cell Res. 192, 469–480.

    Article  PubMed  Google Scholar 

  • Meda, P., Pepper, M., Traub, O., Willecke, K., Gros, D., Beyer, E., Nicholson, B., Paul, D., and Orci, L. (1993).Endocrinology 133, 2371–2378.

    Article  PubMed  Google Scholar 

  • Meda, P., Vozzi, C., Ullrich, S., Dupont, E., Charollais, A., Sutter, E., and Bosco, D. (1995). InProgress in Cell Research, Vol. 4 (Kanno, Y. Kataoka, K., Shiba, Y., Shibata, Y., and Shimazu, T., eds.), Elsevier Science B.V., Amsterdam, pp. 281–287.

    Google Scholar 

  • Meissner, H. P. (1976).Nature 262, 502–504.

    Article  PubMed  Google Scholar 

  • Miller, S. M., Garfield, R. E., and Daniel, E. E. (1989).Am. J. Physiol. 256, C130-C141.

    PubMed  Google Scholar 

  • Munari-Silem, Y., Mesnil, M., Selmi, S., Bernier-Valentin, F., Rabilloud, R., Rousset, B. (1990).J. Cell Physiol. 145, 414–427.

    Article  PubMed  Google Scholar 

  • Munari-Silem, Y., Audebet, C., and Rousset, B. (1991).Endocrinology 128, 3299–3309.

    PubMed  Google Scholar 

  • Munari-Silem, Y., Lebrethon, M. C., Morand, I., Rousset, B., and Saez, J. M. (1995).J. Clin. Invest. 95, 1429–1439.

    PubMed  Google Scholar 

  • Murray, S. A., and Fletcher, W. H. (1984)J. Cell Biol. 98, 1710–1719.

    Article  PubMed  Google Scholar 

  • Musil, L. S., and Goodenough, D. A. (1990).Curr. Opin. Cell Biol. 2, 875–880.

    Article  PubMed  Google Scholar 

  • Petersen, C. C., and Petersen, O. H. (1991).FEBS Lett. 284, 113–116.

    Article  PubMed  Google Scholar 

  • Petersen, O. H., and Findlay, I. (1987).Physiol. Rev. 67, 1054–1116.

    PubMed  Google Scholar 

  • Philippe, J., Giordano, E., Gjinovci, A., and Meda, P. (1992).J. Clin. Invest. 90, 2228–2233.

    PubMed  Google Scholar 

  • Pipeleers, D. (1984).Experientia 40, 1114–1126.

    Article  PubMed  Google Scholar 

  • Ramondt, J., Verhoeff, A., Garfield, R. E., and Wallenburg, H. C. (1994).Eur. J. Obstet. Gynecol. Reprod. Biol. 54, 63–69.

    Article  PubMed  Google Scholar 

  • Sáez, J. C., Connor, J. A., Spray, D. C., Bennett, M. V. L. (1989).Proc. Natl. Acad. Sci. USA 86, 2708–2712.

    PubMed  Google Scholar 

  • Salomon, D., and Meda, P. (1986).Exp. Cell Res. 162, 507–520.

    Article  PubMed  Google Scholar 

  • Sasaki, Y., Shiba, Y., and Kanno, Y. (1988).Jpn. J. Physiol. 38, 531–543.

    PubMed  Google Scholar 

  • Schuit, F. C., In't Veld, P. A., and Pipeleers, D. G. (1988).Proc. Natl. Acad. Sci. USA 85, 3865–3869.

    PubMed  Google Scholar 

  • Seseke, F. G., Gardemann, A., and Jungermann, K. (1992).FEBS Lett. 301, 265–270.

    Article  PubMed  Google Scholar 

  • Sorenson, R. L., and Parsons, J. A. (1985).Diabetes 34, 338–341.

    Google Scholar 

  • Stagg, R. B., and Fletcher, W. H. (1990).Endocr. Rev. 11, 302–325.

    PubMed  Google Scholar 

  • Stefan, Y., Meda, P., Neufeld, M., and Orci, L. (1987).J. Clin. Invest. 80, 175–183.

    PubMed  Google Scholar 

  • Stutenkemper, R., Geisse, S., Schwarz, H. J., Look, J., Traub, O., Nicholson, B. J., and Willecke, K. (1992).Exp. Cell Res. 201, 43–54.

    Article  PubMed  Google Scholar 

  • Sugita, M., Shiba, Y., and Kanno, Y. (1995). InProgress in Cell Research, Vol. 4 (Kanno, Y., Kataoka, K., Shiba, Y., Shibata, Y., and Shimazu, T., eds.), Elsevier Science B. V., Amsterdam, pp. 313–316.

    Google Scholar 

  • Valdeolmillos, M., Nadal, A., Soria, B., and Garcia-Sancho, J. (1993).Diabetes 42, 1210–1214.

    PubMed  Google Scholar 

  • Vozzi, C., Ullrich, S., Charollais, A., Philippe, J., Orci, L., and Meda, P. (1995).J. Cell Biol. 131, 1561–1572.

    Article  PubMed  Google Scholar 

  • Yu, W., Dahl, G., and Werner, R. (1994).Proc. R. Soc. London B. Biol. Sci. 255, 125–132.

    Google Scholar 

Download references

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  1. Department of Morphology, University of Geneva Medical School, CH-1211, Genève 4, Switzerland

    Paolo Meda

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Meda, P. The role of gap junction membrane channels in secretion and hormonal action. J Bioenerg Biomembr 28, 369–377 (1996). https://doi.org/10.1007/BF02110113

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  • DOI: https://doi.org/10.1007/BF02110113

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