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Somatodendritic 5-HT1A receptors are critically involved in the anxiolytic effects of 8-OH-DPAT

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Abstract

In the rat shock-induced ultrasonic vocalization test, the anxiolytic effects of the 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) obtained after systemic (IP) and intracerebral injection into the dorsal raphe nucleus (DRN) were selectively abolished by pretreatment with the 5-HT1A receptor antagonist WAY-100635 [N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl) cyclo-hexanecarboxamide trihydrochloride]. This blockade was demonstrated both after systemic and DRN application of WAY-100635. Therefore, it is concluded that the anxiolytic effects of 8-OH-DPAT are mediated by activation of somatodendritic 5-HT1A receptors.

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Authors and Affiliations

  1. Institute for Neurobiology, Troponwerke GmbH & Co. KG, Berliner Strasse 156, D-51063, Köln, Germany

    S. Maurel Remy, R. Schreiber, M. Dalmus & J. De Vry

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  1. S. Maurel Remy
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  2. R. Schreiber
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  3. M. Dalmus
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  4. J. De Vry
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Remy, S.M., Schreiber, R., Dalmus, M. et al. Somatodendritic 5-HT1A receptors are critically involved in the anxiolytic effects of 8-OH-DPAT. Psychopharmacology 125, 89–91 (1996). https://doi.org/10.1007/BF02247397

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  • DOI: https://doi.org/10.1007/BF02247397

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