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Transient increase of tenascin-C in immature hippocampus: astroglial and neuronal expression

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Journal of Neurocytology

Summary

In the present report we describe the anatomical localization of cells expressing tenascin-C, an extracellular matrix glycoprotein, in the hippocampal complex of developing rats. We report a development-dependent down regulation of both tenascin-C protein and mRNA. The highest levels of expression of tenascin-C was observed in rat pups from embryonic day 18 to postnatal day 7. Double labelling experiments performed with a tenascin-C antibody or tenascin-C probes combined with specific markers of astrocytes (GFAP) or neurons (MAP2 and Tau) allowed us to demonstrate that tenascin-C is expressed by both immature astrocytes and neurons in immature hippocampus. The temporal and topographic distribution of cells expressing of post-mitotic cells. In view of these data we discuss the hypothesis that tenascin-C, as a mediator of neuron-glia interaction, may contribute to the development of hippocampal cells.

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Authors and Affiliations

  1. INSERM U29, Université René Descartes (Paris V), 123 Bd, Port Royal, 75674, Paris Cedex 14, France

    L. Ferhat, N. Chevassus au Louis, I. Jorquera, J. Niquet, M. Khrestchatisky, Y. Ben-Ari & A. Represa

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  1. L. Ferhat
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  2. N. Chevassus au Louis
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  3. I. Jorquera
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  4. J. Niquet
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  5. M. Khrestchatisky
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  6. Y. Ben-Ari
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  7. A. Represa
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Ferhat, L., au Louis, N.C., Jorquera, I. et al. Transient increase of tenascin-C in immature hippocampus: astroglial and neuronal expression. J Neurocytol 25, 53–66 (1996). https://doi.org/10.1007/BF02284785

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  • DOI: https://doi.org/10.1007/BF02284785

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