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Empirical evidence that the state dependence and drug discrimination paradigms can generate different outcomes

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Abstract

The study compared the outcomes generated by the State Dependence and Drug Discrimination paradigms with ethanol in the rat. Food-deprived rats learned to complete a fixed-ratio 10 schedule of bar presses for food within 120 s while treated with 320- to 1250-mg/kg doses of ethanol. Subsequent tests of recall of this response with saline failed to generate any evidence that transfer was hampered following the drug-to-saline state change. In contrast, each of 14 rats learned to discriminate 1250 mg/kg ethanol from saline in a Drug Discrimination procedure that also required the animals to press one of two levers for food according to a fixed- ratio 10 schedule. The results offer the first empirical evidence to demonstrate directly that the State Dependence and Drug Discrimination paradigms can generate different outcomes in otherwise identical experimental conditions.

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  1. Centre de Recherche Pierre Fabre, 17 avenue Jean Moulin, F-81106, Castres Cedex, France

    F. C. Colpaert & W. Koek

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  1. F. C. Colpaert
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  2. W. Koek
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Colpaert, F.C., Koek, W. Empirical evidence that the state dependence and drug discrimination paradigms can generate different outcomes. Psychopharmacology 120, 272–279 (1995). https://doi.org/10.1007/BF02311174

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