Summary
Microflow was continuously recorded at four sites of the brain cortex (cat) during and after direct electrical stimulation of the brain. In some experiments local oxygen partial pressure (P o 2) was additionally measured with a new combined element in the same capillary area where microflow was determined. This simultaneous measurement of both microflow and localP o 2 in the tissue enabled us to analyze the kinetics of microflow and its dependence on localP o 2 during activation. Microflow increased at all sites measured, in most cases within 1–2 s after the beginning of stimulation, reached the maximum of hyperemia after the end of stimulation and then gradually returned to the initial level within 30 s up to several minutes according to the intensity of the stimulation. The reaction pattern of microflow was uniform. As localP o 2 normally did not decrease and did not even show an initial decrease after the onset of stimulation, the hyperemia could not be caused by local hypoxia. On the contrary, localP o 2 always increased with the increase of microflow. ThisP o 2 increase is necessary, because the tissue which consumes more oxygen needs higherP o 2 gradients to transport the oxygen to the mitochondria.
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Leniger-Follert, E., Lübbers, D.W. Behavior of microflow and localP O 2 of the brain cortex during and after direct electrical stimulation. Pflugers Arch. 366, 39–44 (1976). https://doi.org/10.1007/BF02486558
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DOI: https://doi.org/10.1007/BF02486558