Abstract
Neuronal peptides exert neurohormonal and neurotransmitter (neuromodulator) functions in the central nervous system (CNS). Besides these functions, a group of neuropeptides may have a capacity to create cell proliferation, growth, and survival. Axotomy induces transient (1–21 d) upregulation of synthesis and gene expression of neuropeptides, such as galanin, corticotropin releasing factor, dynorphin, calcitonin gene-related peptide, vasoactive intestinal polypeptide, cholecystokinin, angiotensin II, and neuropeptide Y. These neuropeptides are colocalized with “classic” neurotransmitters (acetylcholine, aspartate, glutamate) or neurohormones (vasopressin, oxytocin) that are downregulated by axotomy in the same neuronal cells. It is more likely that neuronal cells, in response to axotomy, increase expression of neuropeptides that promote their survival and regeneration, and may downregulate substances related to their transmitter or secretory activities.
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Ágoston D. V., Komoly S., and Palkovits M. (1994)Exp. Neurol. 126, 247–255.
Arvidsson U., Cullheim S., Ulfhake B., Hökfelt T., and Terenius L. (1989)Brain Res. 489, 387–391.
Arvidsson U., Johnson H., Piehl F., Cullheim S., Hökfelt T., Risling M., Terenius L., and Ulfhake B. (1990)Exp. Brain Res. 79, 212–216.
Brecht S., Gass P., Anton F., Bravo R., Zimmermann M., and Herdegen T. (1994)Mol. Cell. Neurosci. 5, 431–441.
Buriani A., Savage M. J., Burmeister D. W., and Goldberg D. J. (1990)J. Neurochem. 55, 1817–1820.
Cho H. J. and Basbaum A. I. (1988)Neurosci. Lett. 84, 125–130.
Cortés R., Ceccatelli S., Schalling M., and Hökfelt T. (1990a)Synapse 6, 369–391.
Cortés R., Villar M. J., Verhofstad A., and Hökfelt T. (1990b)Proc. Natl. Acad. Sci. USA 87, 7742–7746.
Csiffáry A., Ruttner Z., Tóth Zs., and Palkovits M. (1992)Neuroendocrinology 56, 429–435.
de Jong W. and Palkovits M. (1975)Life Sci. 18, 61–64.
Dumoulin F. L., Raivich G., Streit W. J., and Kreutzberg G. W. (1991)Eur. J. Neurosci. 3, 338–342.
Faden A. L., Molineaux C. J., Rosenberg J. G., Jacobs T. P., and Cox B. M. (1985)Regul. Pept. 11, 35–41.
Fodor M. and Palkovits M. (1991)Neurosci. Lett. 133, 195–198.
Haas C. A., Donath C., and Kreutzberg G. W. (1993)Neuroscience 53, 91–99.
Haas C. A., Streit W. J., and Kreutzberg G. W. (1990)J. Neurosci. Res. 27, 272–275.
haddad A., Iucif S., and Cruz A. R. (1969)J. Neurochem. 16, 865–868.
Herdegen T., Kummer W., Fiallos C. E., Leah J., and Bravo R. (1991)Neuroscience 45, 413–422.
Hökfelt T. (1991)Neuron 7, 867–879.
Hökfelt T., Meister B., Everitt B., Staines W., Melander T., Schalling M., Mutt V., Hulting A.-L., Werner S., Bartfai T., Nordström Ö., Fahrenkrug J., and Goldstein M. (1987a) inIntegrative Neuroendocrinology: Molecular, Cellular and Clinical Aspects (McCann S. M. and Weiner R. I., eds.), Karger, Basel, pp. 1–34.
Hökfelt T., Millhorn D., Seroogy K., Tsuruo Y., Ceccatelli S., Lindh B., Meister B., Melander T., Schalling M., Bartfai T., and Terenius L. (1987b)Experientia 43, 768–780.
Hökfelt T., Zhang X., and Wiesenfeld-Hallin Z. (1994)Trends Neurosci. 17, 22–30.
Lantos T. Á., Görcs T. J., and Palkovits M. (1995)Brain Res. Rev. 20, 209–249.
Linda H., Cullheim S., Risling M., Arvidsson U., Mossberg K., Ulfhake B., Terenius L., and Hökfelt T. (1990)Brain Res. 534, 352–356.
Marlier L., Rajaofetra N., Peretti R. R., Kachidian P., Poulat P., Feuerstein C., and Privat A. (1990)Exp. Brain Res. 82, 40–47.
McCann S. M. (1982) inNeuroendocrine Perspectives, vol. 1 (Müller E. and MacLeod R. E., eds.), Elsevier/North-Holland, Amsterdam, pp. 1–22.
McGregor G. P., Gibson S. J., Sabate I. M., Blank M. A., Christofides N. D., Wall P. D., Polak J. M., and Bloom S. R. (1984)Neuroscience 13, 207–216.
Mezey E. and Palkovits M. (1991)Mol. Brain Res. 10, 55–59.
Moore R. Y. (1989)J. Comp. Neurol. 282, 512–522.
Noguchi K., Senba E., Morita I. Y., Sato M., and Tohyama M. (1990)Mol. Brain Res. 7, 299–304.
Palkovits M. (1982)Peptides 3, 299–303.
Palkovits M. (1988) inFrontiers in neuroendocrinology, vol. 10 (Martini L. and Ganong W. F., eds.), Raven, New York, pp. 1–44.
Palkovits M. and Horváth S. (1994)Acta Biol. Hung. 45, 399–417.
Palkovits M., Kakucska I., and Makara G. B. (1989)Brain Res. 486, 364–368.
Palkovits M., Léránth Cs., Görcs T., and Young S. W. (1987)Proc. Natl. Acad. Sci. USA 84, 3911–3915.
Palkovits M., Mezey É., Skirboll L. R., and Hökfelt T. (1992)J. Chem. Neuroanat. 5, 407–415.
Piehl F., Arvidsson U., Johnson H., Cullheim S., Villar M., Dagerlind A., Terenius L., Hökfelt T., and Ulfhake B. (1991)Eur. J. Neurosci. 3, 737–757.
Rutherfurd S. D., Widdop R. E., Louis W. J., and Gundlach A. L. (1992)Mol. Brain Res. 14, 261–266.
Saika T., Senba E., Noguchi K., Sato M., Kubo T., Matsunaga T., and Tohyama M. (1991)Mol. Brain Res. 11, 187–196.
Schwartz J. P. (1992)Int. Rev. Neurobiol. 34, 1–23.
Selvais P. L., Colin I. M., Adam E., Kasa-Vubu J.-Z., Denef J.-F., and Maiter D. M. (1993)Neuroendocrinology 58, 539–547.
Sheng M. and Greenberg M. (1990)Neuron 4, 477–485.
Smith C. B., Crane M., Kadekaro M., Agranoff B. W., and Sokoloff L. (1984)J. Neurosci. 4, 2489–2496.
Streit W. J., Dumoulin F. L., Raivich G., and Kreutzberg G. W. (1989)Neurosci. Lett. 101, 143–148.
Villar M. J., Meister B., Cortés R., Schalling M., Morris M., and Hökfelt T. (1990)Neuroscience 36, 181–199.
Watson W. E. (1968)J. Physiol. 196, 655–676.
Young W. S. III, Horváth S., and Palkovits M. (1990)Neuroscience 39, 115–125.
Young W. S. III, Mezey É., and Siegel R. E. (1986)Neurosci. Lett. 70, 198–203.
Zhang X., Verge V. M. K., Wiesenfeld-Hallin Z., Piehl F., and Hökfelt T. (1993)Exp. Brain Res. 93, 450–461.
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Palkovits, M. Neuropeptide messenger plasticity in the CNS neurons following axotomy. Mol Neurobiol 10, 91–103 (1995). https://doi.org/10.1007/BF02740669
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DOI: https://doi.org/10.1007/BF02740669