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Injury-induced neurogenesis in the mammalian forebrain

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Abstract

It has been accepted that new neurons are added to the olfactory bulb and the hippocampal dentate gyrus throughout life in the healthy adult mammalian brain. Recent studies have clarified that brain insult raises the proliferation of neural stem cells/neural progenitor cells existing in the subventricular zone and the subgranular zone, which become sources of new neurons for the olfactory bulb and the dentate gyrus, respectively. Interestingly, convincing data has shown that brain insult invokes neurogenesis in various brain regions, such as the hippocampal cornu ammonis region, striatum, and cortex. These reports suggest that neural stem cells/neural progenitor cells, which can be activated by brain injury, might be broadly located in the adult brain or that new neurons may migrate widely from the neurogenic regions. This review focuses on brain insult-induced neurogenesis in the mammalian forebrain, especially in the neocortex.

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Abbreviations

BrdU:

Bromodeoxyuridine

CA:

Cornu ammonis

L1-INP:

Layer 1 inhibitory neuron progenitor

MGE:

Medial ganglionic eminence

NSC:

Neural stem cell

NPC:

Neural progenitor cell

SGZ:

Subgranular zone

SVZ:

Subventricular zone

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Acknowledgments

I thank Dr. Greta Anderson for critical reading of the manuscript. This work was supported by the Ministry of Education, Culture, Sports, Science and Technology, Grants-in-Aid for Young Scientists (B), 21700384.

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  1. Division of Systems Medical Science, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi, 470-1192, Japan

    Koji Ohira

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Ohira, K. Injury-induced neurogenesis in the mammalian forebrain. Cell. Mol. Life Sci. 68, 1645–1656 (2011). https://doi.org/10.1007/s00018-010-0552-y

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  • DOI: https://doi.org/10.1007/s00018-010-0552-y

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