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Monoaminergic modulation of behavioural and electrophysiological indices of error processing

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Abstract

Rationale

Error processing is a critical executive function that is impaired in a large number of clinical populations. Although the neural underpinnings of this function have been investigated for decades and critical error-related components in the human electroencephalogram (EEG), such as the error-related negativity (ERN) and the error positivity (Pe), have been characterised, our understanding of the relative contributions of key neurotransmitters to the generation of these components remains limited.

Objectives

The current study sought to determine the effects of pharmacological manipulation of the dopamine, noradrenaline and serotonin neurotransmitter systems on key behavioural and event-related potential correlates of error processing.

Methods

A randomised, double-blinded, placebo-controlled, crossover design was employed. Monoamine levels were manipulated using the clinically relevant drugs methylphenidate, atomoxetine and citalopram, in comparison to placebo. Under each of the four drug conditions, participants underwent EEG recording while performing a flanker task.

Results

Only methylphenidate produced significant improvement in performance accuracy, which was without concomitant slowing of reaction time. Methylphenidate also increased the amplitude of an early electrophysiological index of error processing, the ERN. Citalopram increased the amplitude of the correct-response negativity, another component associated with response processing.

Conclusions

The effects of methylphenidate in this study are consistent with theoretical accounts positing catecholamine modulation of error monitoring. Our data suggest that enhancing catecholamine function has the potential to remediate the error-monitoring deficits that are seen in a wide range of psychiatric conditions.

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References

  • Agam Y, Hamalainen MS, Lee AK, Dyckman KA, Friedman JS, Isom M, Makris N, Manoach DS (2011) Multimodal neuroimaging dissociates hemodynamic and electrophysiological correlates of error processing. Proc Natl Acad Sci U S A 108:17556–17561

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Arnsten AF (2009) Stress signalling pathways that impair prefrontal cortex structure and function. Nat Rev Neurosci 10:410–422

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Arnsten AF, Dudley AG (2005) Methylphenidate improves prefrontal cortical cognitive function through alpha2 adrenoceptor and dopamine D1 receptor actions: relevance to therapeutic effects in attention deficit hyperactivity disorder. Behav Brain Funct 1:2

    Article  PubMed Central  PubMed  Google Scholar 

  • Aston-Jones G, Cohen JD (2005) Adaptive gain and the role of the locus coeruleus–norepinephrine system in optimal performance. J Comp Neurol 493:99–110

    Article  CAS  PubMed  Google Scholar 

  • Bari A, Aston-Jones G (2013) Atomoxetine modulates spontaneous and sensory-evoked discharge of locus coeruleus noradrenergic neurons. Neuropharmacology 64:53–64

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Barnes JJ, Dean AJ, Nandam LS, O'Connell RG, Bellgrove MA (2011) The molecular genetics of executive function: role of monoamine system genes. Biol Psychiatry 69:e127–e143

    Article  CAS  PubMed  Google Scholar 

  • Berridge CW, Devilbiss DM, Andrzejewski ME, Arnsten AF, Kelley AE, Schmeichel B, Hamilton C, Spencer RC (2006) Methylphenidate preferentially increases catecholamine neurotransmission within the prefrontal cortex at low doses that enhance cognitive function. Brain Res Brain Res Rev 60:1111–1120

    CAS  Google Scholar 

  • Beste C, Domschke K, Kolev V, Yordanova J, Baffa A, Falkenstein M, Konrad C (2010) Functional 5-HT1a receptor polymorphism selectively modulates error-specific subprocesses of performance monitoring. Hum Brain Mapp 31:621–630

    PubMed  Google Scholar 

  • Bond A, Lader M (1974) The use of analogue scales in rating subjective feelings. Br J Med Psychol 47:211–218

    Article  Google Scholar 

  • Botvinick MM, Cohen JD, Carter CS (2004) Conflict monitoring and anterior cingulate cortex: an update. Trends Cogn Sci 8:539–546

    Article  PubMed  Google Scholar 

  • Brazil IA, de Bruijn ER, Bulten BH, von Borries AK, van Lankveld JJ, Buitelaar JK, Verkes RJ (2009) Early and late components of error monitoring in violent offenders with psychopathy. Biol Psychiatry 65:137–143

    Article  PubMed  Google Scholar 

  • Burle B, Roger C, Allain S, Vidal F, Hasbroucq T (2008) Error negativity does not reflect conflict: a reappraisal of conflict monitoring and anterior cingulate cortex activity. J Cogn Neurosci 20:1637–1655

    Article  PubMed  Google Scholar 

  • Bymaster FP, Katner JS, Nelson DL, Hemrick-Luecke SK, Threlkeld PG, Heiligenstein JH, Morin SM, Gehlert DR, Perry KW (2002) Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder. Neuropsychopharmacology 27:699–711

    Article  CAS  PubMed  Google Scholar 

  • Cassidy SM, Robertson IH, O'Connell RG (2012) Retest reliability of event-related potentials: evidence from a variety of paradigms. Psychophysiology 49:659–664

    Article  PubMed  Google Scholar 

  • Chamberlain SR, Del Campo N, Dowson J, Muller U, Clark L, Robbins TW, Sahakian BJ (2007) Atomoxetine improved response inhibition in adults with attention deficit/hyperactivity disorder. Biol Psychiatry 62:977–984

    Article  CAS  PubMed  Google Scholar 

  • Chamberlain SR, Hampshire A, Muller U, Rubia K, Del Campo N, Craig K, Regenthal R, Suckling J, Roiser JP, Grant JE, Bullmore ET, Robbins TW, Sahakian BJ (2009) Atomoxetine modulates right inferior frontal activation during inhibitory control: a pharmacological functional magnetic resonance imaging study. Biol Psychiatry 65:550–555

    Article  CAS  PubMed  Google Scholar 

  • Cools R, D'Esposito M (2011) Inverted-U-shaped dopamine actions on human working memory and cognitive control. Biol Psychiatry 69:e113–e125

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Davies PL, Segalowitz SJ, Gavin WJ (2004) Development of response-monitoring ERPs in 7- to 25-year-olds. Dev Neuropsychol 25:355–376

    Article  PubMed  Google Scholar 

  • Dayan P, Yu AJ (2006) Phasic norepinephrine: a neural interrupt signal for unexpected events. Network 17:335–350

    Article  PubMed  Google Scholar 

  • de Bruijn ER, Hulstijn W, Verkes RJ, Ruigt GS, Sabbe BG (2004) Drug-induced stimulation and suppression of action monitoring in healthy volunteers. Psychopharmacology (Berl) 177:151–160

    Article  CAS  Google Scholar 

  • de Bruijn ER, Sabbe BG, Hulstijn W, Ruigt GS, Verkes RJ (2006) Effects of antipsychotic and antidepressant drugs on action monitoring in healthy volunteers. Brain Res 1105:122–129

    Article  PubMed  Google Scholar 

  • Debener S, Ullsperger M, Siegel M, Fiehler K, von Cramon DY, Engel AK (2005) Trial-by-trial coupling of concurrent electroencephalogram and functional magnetic resonance imaging identifies the dynamics of performance monitoring. J Neurosci 25:11730–11737

    Article  CAS  PubMed  Google Scholar 

  • Dehaene S, Posner MI, Tucker DM (1994) Localization of a neural system for error detection and compensation. Psychol Sci 5:303–305

    Article  Google Scholar 

  • Delorme A, Makeig S (2004) EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis. J Neurosci Methods 134:9–21

    Article  PubMed  Google Scholar 

  • Dockree PM, Kelly SP, Robertson IH, Reilly RB, Foxe JJ (2005) Neurophysiological markers of alert responding during goal-directed behavior: a high-density electrical mapping study. Neuroimage 27:587–601

    Article  PubMed  Google Scholar 

  • Eriksen BA, Eriksen CW (1974) Effects of noise letters upon the identification of a target letter in a non-search task. Percept Psychophys 16:143–149

    Article  Google Scholar 

  • Falkenstein M, Hohnsbein J, Hoormann J, Blanke L (1991) Effects of crossmodal divided attention on late ERP components. II. Error processing in choice reaction tasks. Electroencephalogr Clin Neurophysiol 78:447–455

    Article  CAS  PubMed  Google Scholar 

  • Falkenstein M, Hoormann J, Christ S, Hohnsbein J (2000) ERP components on reaction errors and their functional significance: a tutorial. Biol Psychol 51:87–107

    Article  CAS  PubMed  Google Scholar 

  • Falkenstein M, Hielscher H, Dziobek I, Schwarzenau P, Hoormann J, Sunderman B, Hohnsbein J (2001) Action monitoring, error detection, and the basal ganglia: an ERP study. Neuroreport 12:157–161

    Article  CAS  PubMed  Google Scholar 

  • Fallgatter AJ, Herrmann MJ, Roemmler J, Ehlis AC, Wagener A, Heidrich A, Ortega G, Zeng Y, Lesch KP (2004) Allelic variation of serotonin transporter function modulates the brain electrical response for error processing. Neuropsychopharmacology 29:1506–1511

    Article  CAS  PubMed  Google Scholar 

  • Foti D, Kotov R, Bromet E, Hajcak G (2012) Beyond the broken error-related negativity: functional and diagnostic correlates of error processing in psychosis. Biol Psychiatry 71:864–872

    Article  PubMed Central  PubMed  Google Scholar 

  • Franken IH, van Strien JW, Franzek EJ, van de Wetering BJ (2007) Error-processing deficits in patients with cocaine dependence. Biol Psychol 75:45–51

    Article  PubMed  Google Scholar 

  • Gamo NJ, Wang M, Arnsten AF (2010) Methylphenidate and atomoxetine enhance prefrontal function through alpha2-adrenergic and dopamine D1 receptors. J Am Acad Child Adolesc Psychiatry 49:1011–1023

    Article  PubMed Central  PubMed  Google Scholar 

  • Geburek AJ, Rist F, Gediga G, Stroux D, Pedersen A (2012) Electrophysiological indices of error monitoring in juvenile and adult attention deficit hyperactivity disorder (ADHD)—a meta-analytic appraisal. Int J Psychophysiol 87:349–362

    Article  PubMed  Google Scholar 

  • Gehring WJ, Goss B, Coles MGH, Meyer DE, Donchin EA (1993) Neural system for error-detection and compensation. Psychol Sci 4:385–390

    Article  Google Scholar 

  • Gehring WJ, Himle J, Nisenson LG (2000) Action-monitoring dysfunction in obsessive-compulsive disorder. Psychol Sci 11:1–6

    Article  CAS  PubMed  Google Scholar 

  • Gratton G, Coles MG, Donchin E (1992) Optimizing the use of information: strategic control of activation of responses. J Exp Psychol Gen 121:480–506

    Article  CAS  PubMed  Google Scholar 

  • Hajcak G, Moser JS, Yeung N, Simons RF (2005) On the ERN and the significance of errors. Psychophysiology 42:151–160

    Article  PubMed  Google Scholar 

  • Han DD, Gu HH (2006) Comparison of the monoamine transporters from human and mouse in their sensitivities to psychostimulant drugs. BMC Pharmacol 6:6

    Article  PubMed Central  PubMed  Google Scholar 

  • Herrmann MJ, Rommler J, Ehlis AC, Heidrich A, Fallgatter AJ (2004) Source localization (LORETA) of the error-related-negativity (ERN/Ne) and positivity (Pe). Brain Res Cogn Brain Res 20:294–299

    Article  PubMed  Google Scholar 

  • Herrmann MJ, Mader K, Schreppel T, Jacob C, Heine M, Boreatti-Hummer A, Ehlis AC, Scheuerpflug P, Pauli P, Fallgatter AJ (2010) Neural correlates of performance monitoring in adult patients with attention deficit hyperactivity disorder (ADHD). World J Biol Psychiatry 11:457–464

    Article  PubMed  Google Scholar 

  • Holmes AJ, Pizzagalli DA (2008) Spatiotemporal dynamics of error processing dysfunctions in major depressive disorder. Arch Gen Psychiatry 65:179–188

    Article  PubMed Central  PubMed  Google Scholar 

  • Holmes AJ, Bogdan R, Pizzagalli DA (2010) Serotonin transporter genotype and action monitoring dysfunction: a possible substrate underlying increased vulnerability to depression. Neuropsychopharmacology 35:1186–1197

    Article  CAS  PubMed  Google Scholar 

  • Holroyd CB, Coles MG (2002) The neural basis of human error processing: reinforcement learning, dopamine, and the error-related negativity. Psychol Rev 109:679–709

    Article  PubMed  Google Scholar 

  • Holroyd CB, Yeung N, Coles MG, Cohen JD (2005) A mechanism for error detection in speeded response time tasks. J Exp Psychol Gen 134:163–191

    Article  PubMed  Google Scholar 

  • Jonkman LM, van Melis JJ, Kemner C, Markus CR (2007) Methylphenidate improves deficient error evaluation in children with ADHD: an event-related brain potential study. Biol Psychol 76:217–229

    Article  PubMed  Google Scholar 

  • Kramer UM, Cunillera T, Camara E, Marco-Pallares J, Cucurell D, Nager W, Bauer P, Schule R, Schols L, Rodriguez-Fornells A, Munte TF (2007) The impact of catechol-O-methyltransferase and dopamine D4 receptor genotypes on neurophysiological markers of performance monitoring. J Neurosci 27:14190–14198

    Article  PubMed  Google Scholar 

  • Ladouceur CD, Dahl RE, Carter CS (2007) Development of action monitoring through adolescence into adulthood: ERP and source localization. Dev Sci 10:874–891

    Article  PubMed  Google Scholar 

  • Larson MJ, Baldwin SA, Good DA, Fair JE (2010) Temporal stability of the error-related negativity (ERN) and post-error positivity (Pe): the role of number of trials. Psychophysiology 47:1167–1171

    Article  PubMed  Google Scholar 

  • Lee YS, Han DH, Lee JH, Choi TY (2010) The effects of methylphenidate on neural substrates associated with interference suppression in children with ADHD: a preliminary study using event related fMRI. Psychiatry Investig 7:49–54

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Maier ME, di Pellegrino G, Steinhauser M (2012) Enhanced error-related negativity on flanker errors: error expectancy or error significance? Psychophysiology 49:899–908

    Article  PubMed  Google Scholar 

  • McLoughlin G, Albrecht B, Banaschewski T, Rothenberger A, Brandeis D, Asherson P, Kuntsi J (2009) Performance monitoring is altered in adult ADHD: a familial event-related potential investigation. Neuropsychologia 47:3134–3142

    Article  PubMed Central  PubMed  Google Scholar 

  • Millan MJ, Newman-Tancredi A, Audinot V, Cussac D, Lejeune F, Nicolas JP, Coge F, Galizzi JP, Boutin JA, Rivet JM, Dekeyne A, Gobert A (2000) Agonist and antagonist actions of yohimbine as compared to fluparoxan at alpha(2)-adrenergic receptors (AR)s, serotonin (5-HT)(1A), 5-HT(1B), 5-HT(1D) and dopamine D(2) and D(3) receptors. Significance for the modulation of frontocortical monoaminergic transmission and depressive states. Synapse 35:79–95

    Article  CAS  PubMed  Google Scholar 

  • Murphy PR, Robertson IH, Balsters JH, O'Connell RG (2011) Pupillometry and P3 index the locus coeruleus-noradrenergic arousal function in humans. Psychophysiology 48:1532–1543

    Article  PubMed  Google Scholar 

  • Murphy PR, Robertson IH, Allen D, Hester R, O'Connell RG (2012) An electrophysiological signal that precisely tracks the emergence of error awareness. Front Hum Neurosci 6:65

    Article  PubMed Central  PubMed  Google Scholar 

  • Nieuwenhuis S, Ridderinkhof KR, Blom J, Band GP, Kok A (2001) Error-related brain potentials are differentially related to awareness of response errors: evidence from an antisaccade task. Psychophysiology 38:752–760

    Article  CAS  PubMed  Google Scholar 

  • Nieuwenhuis S, Aston-Jones G, Cohen JD (2005) Decision making, the P3, and the locus coeruleus-norepinephrine system. Psychol Bull 131:510–532

    Article  PubMed  Google Scholar 

  • Norris H (1971) The action of sedatives on brain stem oculomotor systems in man. Neuropharmacology 10:181–191

    Article  CAS  PubMed  Google Scholar 

  • O'Connell RG, Dockree PM, Bellgrove MA, Kelly SP, Hester R, Garavan H, Robertson IH, Foxe JJ (2007) The role of cingulate cortex in the detection of errors with and without awareness: a high-density electrical mapping study. Eur J Neurosci 25:2571–2579

    Article  PubMed  Google Scholar 

  • O'Connell RG, Bellgrove MA, Dockree PM, Lau A, Hester R, Garavan H, Fitzgerald M, Foxe JJ, Robertson IH (2009) The neural correlates of deficient error awareness in attention-deficit hyperactivity disorder (ADHD). Neuropsychologia 47:1149–1159

    Article  PubMed  Google Scholar 

  • Ortega JE, Fernandez-Pastor B, Callado LF, Meana JJ (2010) In vivo potentiation of reboxetine and citalopram effect on extracellular noradrenaline in rat brain by alpha2-adrenoceptor antagonism. Eur Neuropsychopharmacol 20:813–822

    Article  CAS  PubMed  Google Scholar 

  • Overbeek TJM, Nieuwenhuis S, Ridderinkhof KR (2005) Dissociable components of error processing: on the functional significance of the Pe vis-à-vis the ERN/Ne. J Psychophysiol 19:319–329

    Article  Google Scholar 

  • Perez VB, Ford JM, Roach BJ, Woods SW, McGlashan TH, Srihari VH, Loewy RL, Vinogradov S, Mathalon DH (2012) Error monitoring dysfunction across the illness course of schizophrenia. J Abnorm Psychol 121:372–387

    Article  PubMed Central  PubMed  Google Scholar 

  • Pontifex MB, Scudder MR, Brown ML, O'Leary KC, Wu CT, Themanson JR, Hillman CH (2010) On the number of trials necessary for stabilization of error-related brain activity across the life span. Psychophysiology 47:767–773

    PubMed  Google Scholar 

  • Potts GF (2011) Impact of reward and punishment motivation on behavior monitoring as indexed by the error-related negativity. Int J Psychophysiol 81:324–331

    Article  PubMed Central  PubMed  Google Scholar 

  • Rabbitt PM (1966) Errors and error correction in choice-response tasks. J Exp Psychol 71:264–272

    Article  CAS  PubMed  Google Scholar 

  • Riba J, Rodriguez-Fornells A, Morte A, Munte TF, Barbanoj MJ (2005) Noradrenergic stimulation enhances human action monitoring. J Neurosci 25:4370–4374

    Article  CAS  PubMed  Google Scholar 

  • Ridderinkhof KR, Ramautar JR, Wijnen JG (2009) To P(E) or not to P(E): a P3-like ERP component reflecting the processing of response errors. Psychophysiology 46:531–538

    Article  PubMed  Google Scholar 

  • Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, Hergueta T, Baker R, Dunbar GC (1998) The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry 59(Suppl 20):22–33, quiz 34-57

    PubMed  Google Scholar 

  • Shiels K, Hawk LW Jr (2010) Self-regulation in ADHD: the role of error processing. Clin Psychol Rev 30:951–961

    Article  PubMed Central  PubMed  Google Scholar 

  • Steinhauser M, Yeung N (2010) Decision processes in human performance monitoring. J Neurosci 30:15643–15653

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Stemmer B, Segalowitz SJ, Dywan J, Panisset M, Melmed C (2007) The error negativity in nonmedicated and medicated patients with Parkinson's disease. Clin Neurophysiol 118:1223–1229

    Article  PubMed  Google Scholar 

  • Szabo ST, Blier P (2001) Effect of the selective noradrenergic reuptake inhibitor reboxetine on the firing activity of noradrenaline and serotonin neurons. The Eur J Neurosci 13:2077–2087

    Article  CAS  Google Scholar 

  • Themanson JR, Rosen PJ, Pontifex MB, Hillman CH, McAuley E (2012) Alterations in error-related brain activity and post-error behavior over time. Brain Cogn 80:257–265

    Article  PubMed  Google Scholar 

  • Thomas DN, Nutt DJ, Holman RB (1998) Sertraline, a selective serotonin reuptake inhibitor modulates extracellular noradrenaline in the rat frontal cortex. J Psychopharmacol 12:366–370

    Article  CAS  PubMed  Google Scholar 

  • Tieges Z, Richard Ridderinkhof K, Snel J, Kok A (2004) Caffeine strengthens action monitoring: evidence from the error-related negativity. Brain Res Cogn Brain Res 21:87–93

    Article  CAS  PubMed  Google Scholar 

  • Ullsperger M, Harsay HA, Wessel JR, Ridderinkhof KR (2010) Conscious perception of errors and its relation to the anterior insula. Brain Struct Funct 214:629–643

    Article  PubMed Central  PubMed  Google Scholar 

  • Varnas K, Halldin C, Hall H (2004) Autoradiographic distribution of serotonin transporters and receptor subtypes in human brain. Hum Brain Mapp 22:246–260

    Article  PubMed  Google Scholar 

  • Vidal F, Hasbroucq T, Grapperon J, Bonnet M (2000) Is the ‘error negativity’ specific to errors? Biol Psychol 51:109–128

    Article  CAS  PubMed  Google Scholar 

  • Volkow ND, Wang G, Fowler JS, Logan J, Gerasimov M, Maynard L, Ding Y, Gatley SJ, Gifford A, Franceschi D (2001) Therapeutic doses of oral methylphenidate significantly increase extracellular dopamine in the human brain. J Neurosci 21:RC121

    CAS  PubMed  Google Scholar 

  • Volkow ND, Fowler JS, Wang G, Ding Y, Gatley SJ (2002) Mechanism of action of methylphenidate: insights from PET imaging studies. J Atten Disord 6(Suppl 1):S31–S43

    PubMed  Google Scholar 

  • Wardle MC, Yang A, de Wit H (2012) Effect of d-amphetamine on post-error slowing in healthy volunteers. Psychopharmacology (Berl) 220:109–115

    Article  CAS  Google Scholar 

  • Wessel JR (2012) Error awareness and the error-related negativity: evaluating the first decade of evidence. Front Hum Neurosci 6:88

    Article  PubMed Central  PubMed  Google Scholar 

  • Wessel JR, Danielmeier C, Morton JB, Ullsperger M (2012) Surprise and error: common neuronal architecture for the processing of errors and novelty. J Neurosci 32:7528–7537

    Article  CAS  PubMed  Google Scholar 

  • Wiersema JR, van der Meere JJ, Roeyers H (2009) ERP correlates of error monitoring in adult ADHD. J Neural Transm 116:371–379

    Article  CAS  PubMed  Google Scholar 

  • Willemssen R, Muller T, Schwarz M, Hohnsbein J, Falkenstein M (2008) Error processing in patients with Parkinson's disease: the influence of medication state. J Neural Transm 115:461–468

    Article  CAS  PubMed  Google Scholar 

  • Yeung N, Botvinick MM, Cohen JD (2004) The neural basis of error detection: conflict monitoring and the error-related negativity. Psychol Rev 111:931–959

    Article  PubMed  Google Scholar 

  • Zirnheld PJ, Carroll CA, Kieffaber PD, O'Donnell BF, Shekhar A, Hetrick WP (2004) Haloperidol impairs learning and error-related negativity in humans. J Cogn Neurosci 16:1098–1112

    Article  PubMed  Google Scholar 

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Acknowledgments

This work was supported by a grant from the National Health and Medical Research Council of Australia (NHMRC) (569532) to MAB. MAB is supported by a Career Development Award from the NHMRC, Australia. We would like to thank the Wesley Hospital Pharmacy for dispensing the drugs associated with this project.

Conflict of interest

Both LSN and MAB have received reimbursement from Lilly Pharmaceuticals for conference travel expenses and for speaking at conferences. The author MAB has received speaker's fees from Janssen-Cilag. The author LSN has received speaker's fees from AstraZeneca, Bristol-Myers Squibb, Boehringer Ingelheim and Janssen-Cilag. The authors JJMB, RGO and AJD report no biomedical financial interests or potential conflicts of interest.

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Authors and Affiliations

  1. The University of Queensland, Queensland Brain Institute, Brisbane, Australia

    Jessica J. M. Barnes, L. Sanjay Nandam, Angela J. Dean & Mark A. Bellgrove

  2. Trinity College Institute of Neuroscience, Dublin, Ireland

    Redmond G. O’Connell

  3. School of Psychology and Psychiatry, Monash University, Melbourne, VIC, 3800, Australia

    Mark A. Bellgrove

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  1. Jessica J. M. Barnes
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  2. Redmond G. O’Connell
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  3. L. Sanjay Nandam
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Correspondence to Mark A. Bellgrove.

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Barnes, J.J.M., O’Connell, R.G., Nandam, L.S. et al. Monoaminergic modulation of behavioural and electrophysiological indices of error processing. Psychopharmacology 231, 379–392 (2014). https://doi.org/10.1007/s00213-013-3246-y

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