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Changes in corticomotor excitability of hand muscles in relation to static shoulder positions

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Abstract

We examined whether the recruitment properties of the corticospinal pathway to intrinsic hand muscles are influenced by variations of the shoulder joint angle. Abductor digiti minimi (ADM) motor evoked potentials (MEPs) in response to transcranial magnetic stimulation were examined during different static positions of the shoulder joint in the horizontal plane from 30° adduction to 30° abduction with respect to the neutral position at 0°, while elbow and wrist joints were constrained statically at 90° and 180° respectively. We found that 30° abduction of the shoulder significantly depressed MEP size and prolonged MEP latency in comparison with 30° shoulder adduction. The neutral shoulder angle position (at 0°) significantly reduced MEP size but had no effect on MEP latency in comparison with 30° shoulder abduction. The input–output relationship between MEP size and stimulus intensity was sigmoidal. The plateau value and maximum slope were significantly lower at 30° abduction than at 30° adduction of the shoulder. However, the threshold value did not differ significantly between the two positions. To differentiate excitability changes at cortical versus subcortical sites, intracortical inihibition (ICI) and intracortical facilitation (ICF) were assessed using a paired-magnetic pulse paradigm. A significant decrease in ICF was observed after changing shoulder position from 30° adduction to 30° abduction. In contrast, no variation in the amount of ICI occurred in relation to the same changes in shoulder position. ADM F-waves elicited by electrical stimulation of the ulnar nerve at the wrist were significantly decreased at 30° shoulder abduction in comparison with 30° adduction. A similar pattern was observed in one subject in whom the H-reflex could be exceptionally elicited in ADM. We conclude that shoulder position influences the recruitment efficiency (gain) of the corticospinal volleys to motoneurons of intrinsic hand muscles. It is proposed that activity of peripheral receptors signalling static shoulder position influences corticomotor excitability of hand muscles both at the cortical and at the spinal level. This modulation may be functionally relevant when reaching to grasp objects.

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Acknowledgements

This study was funded in part by a University of Siena Research Grant (PAR 2003). We thank R. della Volpe, P. Milani, R. Spidalieri and T. Popa for their assistance during some of the experiments.

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Authors and Affiliations

  1. Sezione di Neurofisiologia Clinica, Dipartimento di Scienze Neurologiche e del Comportamento, Universita’ degli Studi di Siena, Viale Bracci, 53100, Siena, Italy

    F. Ginanneschi, F. Del Santo, F. Dominici, F. Gelli, R. Mazzocchio & A. Rossi

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  1. F. Ginanneschi
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  2. F. Del Santo
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  3. F. Dominici
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  4. F. Gelli
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  5. R. Mazzocchio
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  6. A. Rossi
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Correspondence to A. Rossi.

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Ginanneschi, F., Del Santo, F., Dominici, F. et al. Changes in corticomotor excitability of hand muscles in relation to static shoulder positions. Exp Brain Res 161, 374–382 (2005). https://doi.org/10.1007/s00221-004-2084-x

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  • DOI: https://doi.org/10.1007/s00221-004-2084-x

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