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Impaired conflict monitoring in Parkinson’s disease patients during an oculomotor redirect task

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Abstract

Fallibility is inherent in human cognition and so a system that will monitor performance is indispensable. While behavioral evidence for such a system derives from the finding that subjects slow down after trials that are likely to produce errors, the neural and behavioral characterization that enables such control is incomplete. Here, we report a specific role for dopamine/basal ganglia in response conflict by accessing deficits in performance monitoring in patients with Parkinson’s disease. To characterize such a deficit, we used a modification of the oculomotor countermanding task to show that slowing down of responses that generate robust response conflict, and not post-error per se, is deficient in Parkinson’s disease patients. Poor performance adjustment could be either due to impaired ability to slow RT subsequent to conflicts or due to impaired response conflict recognition. If the latter hypothesis was true, then PD subjects should show evidence of impaired error detection/correction, which was found to be the case. These results make a strong case for impaired performance monitoring in Parkinson’s patients.

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Acknowledgments

We thank Jitender Ahlawat for manuscript preparation. This work was supported by grants from the Department of Science and Technology (DST) and the Department of Biotechnology (DBT), Government of India.

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Authors and Affiliations

  1. National Brain Research Centre, Near NSG Campus, Nainwal More, Manesar, HR, 122050, India

    Ausaf A. Farooqui, Neha Bhutani, Shrikanth Kulashekhar & Aditya Murthy

  2. MRC Cognition and Brain Science Unit, Cambridge, UK

    Ausaf A. Farooqui

  3. Neuroscience Centre, University of Helsinki, Helsinki, Finland, UK

    Shrikanth Kulashekhar

  4. Department of Neurology, CN Centre, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India

    Madhuri Behari & Vinay Goel

  5. Centre for Neuroscience, Indian Institute of Science, Bangalore, 560012, Karnataka, India

    Aditya Murthy

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  1. Ausaf A. Farooqui
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  2. Neha Bhutani
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  3. Shrikanth Kulashekhar
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  4. Madhuri Behari
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  5. Vinay Goel
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  6. Aditya Murthy
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Correspondence to Aditya Murthy.

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Farooqui, A.A., Bhutani, N., Kulashekhar, S. et al. Impaired conflict monitoring in Parkinson’s disease patients during an oculomotor redirect task. Exp Brain Res 208, 1–10 (2011). https://doi.org/10.1007/s00221-010-2432-y

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  • DOI: https://doi.org/10.1007/s00221-010-2432-y

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