Abstract
The elucidation of mechanisms of chromatin remodeling, particular transcriptional activation, and repression by histone acetylation and deacetylation has shed light on the role of histone deacetylases (HDAC) as a new kind of therapeutic target for human cancer treatment. HDACs, in general, act as components of large corepressor complexes that prevent the transcription of several tumor suppression genes. In addition, they appear to be also involved in the deacetylation of nonhistone proteins. This paper reviews the most recent insights into the diverse biological roles of HDACs as well as the evolution of this important protein family.
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Acknowledgement
This work was in part supported by grant BioFuture 0311852 from the Bundesministerium für Forschung und Technologie, Germany and HFSP grant RGY56/2004. The authors are grateful to colleagues in the field for sharing valuable information, in particular T. Beckers, R. Ficner, S. Guccione, M. Jung, A. Kuhn, F.-J. Meyer-Almes, R. Schneider, D. Wegener, H. Weinmann, and O. Witt. A.S. thanks K. Schwienhorst and the staff at the FSZ Hannover for critically reading the manuscript. A.S. also would like to thank all his coworkers for many years of fruitful research and a friendly atmosphere.
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Hildmann, C., Riester, D. & Schwienhorst, A. Histone deacetylases—an important class of cellular regulators with a variety of functions. Appl Microbiol Biotechnol 75, 487–497 (2007). https://doi.org/10.1007/s00253-007-0911-2
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DOI: https://doi.org/10.1007/s00253-007-0911-2