Skip to main content
Log in

The IgG Fc receptor family

Annals of Hematology Aims and scope Submit manuscript

Abstract.

IgG immune complexes are of central importance in the humoral immune system and strongly implicated in the pathogenesis of hematologic and rheumatic autoimmune disorders. Cross-linking of receptors for the Fc domain of IgG antibodies (FcγRs) triggers a wide variety of effector functions including phagocytosis, antibody-dependent cellular cytotoxicity, and release of inflammatory mediators, as well as immune complex clearance and regulation of antibody production. In this way, FcγR provide an essential feedback between the humoral and cellular immune response. In the past, significant advances have been made in the molecular dissection of FcγR function using cellular transfection systems. Current approaches designed to target and change individual FcγR genes in mice have given further insight into their specific contributions to systemic processes, also indicating them to be important immunoregulatory receptors involved in various disease states of allergy, autoimmunity, and inflammation. Future work on targeting FcγR binding sites in combination with humanized FcγR mouse models will lead to novel therapeutic strategies in the treatment of IgG-mediated human disease in which FcγR activation plays an integral part.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Author information

Authors and Affiliations

Authors

Additional information

Received: January 28, 1998 / Accepted: March 31, 1998

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gessner, J., Heiken, H., Tamm, A. et al. The IgG Fc receptor family. Ann Hematol 76, 231–248 (1998). https://doi.org/10.1007/s002770050396

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s002770050396

Navigation