Skip to main content

Advertisement

SpringerLink
Log in

Filament heterogeneity within the dystrophic neurites of senile plaques suggests blockage of fast axonal transport in Alzheimer's disease

  • Regular paper
  • Published:
Acta Neuropathologica Aims and scope Submit manuscript

Abstract

In this study, the direct comparison of biopsy and autopsy tissue by morphological and immunocytochemical techniques, respectively, was used to document cytoskeletal changes of dystrophic neurites (DN) of senile plaques in Alzheimer's disease. This dual approach demonstrated several unreported abnormalities which, together with analogous findings in several experimental models, suggest that DN are associated with deficiencies in fast axonal transport and replacement of the cytoskeleton by an array of related abnormal filaments.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

Author information

Authors and Affiliations

  1. Division of Neuropathology, Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44106-4901, USA Tel.: 1-216-368-2488/216-844-1808; Fax: 1-216-368-8964/216-844-1810; E-mail: gxp7@po.cwru.edu, , , , , , US

    Darja Praprotnik, Mark A. Smith, Peggy L. Richey & G. Perry

  2. Department of Pathology and Laboratory Medicine, UCLA Medical Center, Los Angeles, California, , , , ,

    Harry V. Vinters

Authors
  1. Darja Praprotnik
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mark A. Smith
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Peggy L. Richey
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Harry V. Vinters
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. G. Perry
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Received: 28 July 1995 / Accepted: 8 September 1995

Rights and permissions

Reprints and permissions

About this article

Cite this article

Praprotnik, D., Smith, M., Richey, P. et al. Filament heterogeneity within the dystrophic neurites of senile plaques suggests blockage of fast axonal transport in Alzheimer's disease. Acta Neuropathol 91, 226–235 (1996). https://doi.org/10.1007/s004010050420

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s004010050420

Search

Navigation