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Reversal or reduction of glutamate and GABA transport in CNS pathology and therapy

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Abstract

A dysfunction of amino acid neurotransmitter transporters occurs in a number of central nervous system disorders, including stroke, epilepsy, cerebral palsy and amyotrophic lateral sclerosis. This dysfunction can comprise a reversal of transport direction, leading to the release of neurotransmitter into the extracellular space, or an alteration in transporter expression level. This review analyses the role of glutamate and GABA transporters in the pathogenesis and therapy of a number of acute and chronic neurological disorders.

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Acknowledgements

Supported by the Wellcome Trust, the EU, and a Wolfson-Royal Society Award. N.A. and R.K. were in the 4-year PhD Programme in Neuroscience at University College London.

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  1. Department of Physiology, University College London, Gower Street, London, WC1E 6BT, UK

    Nicola J. Allen, Ragnhildur Káradóttir & David Attwell

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Allen, N.J., Káradóttir, R. & Attwell, D. Reversal or reduction of glutamate and GABA transport in CNS pathology and therapy. Pflugers Arch - Eur J Physiol 449, 132–142 (2004). https://doi.org/10.1007/s00424-004-1318-x

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