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Nitric oxide and MPP+-induced hydroxyl radical generation

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Summary.

Although neuroprotective effect of nitric oxide (NO) is discussed, NO has a role of pathogenesis of cellular injury. NO is synthesized from L-arginine by NO synthase (NOS). NO contributes to the extracellular potassium-ion concentration ([K+]o)-induced hydroxyl radical (•OH) generation. Cytotoxic free radicals such as peroxinitrite (ONOO−) and •OH may also be implicated in NO-mediated cell injury. NO activation was induced by K+ depolarization. NO may react with superoxide anion (O2 −) to form ONOO− and its decomposition generates •OH. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) metabolite 1-methyl-4-phenylpyridinium ion (MPP+) involve toxicity induced by NO. Intraneuronal Ca2+ triggered by MPP+ may be detrimental to the functioning of dopaminergic nerve terminals in the striatum. Although the [K+]o-induced depolarization enhances the formation of •OH product due to MPP+, the •OH generation via NOS activation may be unrelated the dopamine (DA)-induced •OH generation. Depolarization enhances the MPP+-induced •OH formation via NOS activation. NOS inhibition is associated with a protective effect due to suppression of depolarization-induced •OH generation. ONOO− has been implicated as a causative factor under conditions in which DA neurons are damaged. These findings may be useful in elucidating the actual mechanism of free radical formation in the pathogenesis of neurodegenerative brain disorders, including Parkinson’s disease and traumatic brain injuries.

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Abbreviations

MPTP:

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

MPPP:

1-methyl-4-phenyl-4-propionoxy-piperidine

MPP+ :

1-methyl-4-phenylpyridinium ion

MPDP+ :

1-methyl-4-phenyldihydropyridine

ROS:

reactive oxygen species

O2 − :

superoxide anion

•OH:

hydroxyl radical

DA:

dopamine

DHBA:

2,3-dihydroxybenzoic acid

XO:

xanthine oxidase

NOS:

NO synthase

ONOO−, SOD:

peroxinitrite superoxide dismutase

References

  • Y Agid (1991) ArticleTitleParkinson’s disease: pathophysiology Lancet 337 1321–1324 Occurrence Handle1674304 Occurrence Handle1:STN:280:DyaK3M3jt1aqug%3D%3D

    PubMed  CAS  Google Scholar 

  • SG Amara MS Sonders NR Zahniser SL Povlock GM Daniels (1998) ArticleTitleMolecular physiology and regulation of catecholamine transporters Adv Pharmacol 42 164–168 Occurrence Handle9327869 Occurrence Handle1:CAS:528:DyaK2sXntFWqurY%3D Occurrence Handle10.1016/S1054-3589(08)60718-8

    Article  PubMed  CAS  Google Scholar 

  • M Arvin L Fedorkova KA Disshon DE Dluzen RE Leipheimer (2000) ArticleTitleEstrogen modulates responses of striatal dopamine neurons to MPP+: evaluations using in vitro and in vivo techniques Brain Res 872 160–171 Occurrence Handle10924688 Occurrence Handle1:CAS:528:DC%2BD3cXltlekt7Y%3D

    PubMed  CAS  Google Scholar 

  • S Barc G Page L Barrier A Piriou B Fauconneau (2001) ArticleTitleImpairment of the neuronal dopamine transporter activity in MPP+-treated rat was not prevented by treatments with nitric oxide synthase or poly (ADP-ribose) polymerase inhibitors Neurosci Lett 314 82–86 Occurrence Handle11698152 Occurrence Handle1:CAS:528:DC%2BD3MXotFSrs7k%3D

    PubMed  CAS  Google Scholar 

  • JS Beckman TW Beckman J Chen PA Marshall BA Freeman (1990) ArticleTitleApparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide Proc Natl Acad Sci USA 87 1620–1624 Occurrence Handle2154753 Occurrence Handle1:CAS:528:DyaK3cXhvFegsb4%3D

    PubMed  CAS  Google Scholar 

  • JS Beckman H Ischiropoulos L Zhu M van der Woerd C Smith J Chen J Harrison JC Martin M Tsai (1992) ArticleTitleKinetics of superoxide dismutase- and iron-catalyzed nitration of phenolics by peroxynitrite Arch Biochem Biophys 298 438–445 Occurrence Handle1416975 Occurrence Handle1:CAS:528:DyaK3sXhvVCjtQ%3D%3D

    PubMed  CAS  Google Scholar 

  • JS Beckman WH Koppenol (1996) ArticleTitleNitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly Am J Physiol 271 C1424–C1437 Occurrence Handle8944624 Occurrence Handle1:CAS:528:DyaK28XntFymtrc%3D

    PubMed  CAS  Google Scholar 

  • D Ben-Shachar P Riederer MBH Youdim (1991) ArticleTitleIron-melanin interaction and lipid peroxidation: implications for Parkinson’s disease J Neurochem 57 1609–1614 Occurrence Handle1919577 Occurrence Handle1:CAS:528:DyaK3MXmslKqtbY%3D

    PubMed  CAS  Google Scholar 

  • D Blum S Torch N Lambeng M Nissou AL Benabid R Sadoul JM Verna (2001) ArticleTitleMolecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson’s disease Prog Neurobiol 65 135–172 Occurrence Handle11403877 Occurrence Handle1:CAS:528:DC%2BD3MXkt1Kitbo%3D

    PubMed  CAS  Google Scholar 

  • B Bogerts (1981) ArticleTitleA brainstem atlas of catecholaminergic neurons in man, using melanin as a natural marker Comp Neurol 197 63–80 Occurrence Handle1:STN:280:DyaL3M7pt1Gjsw%3D%3D

    CAS  Google Scholar 

  • JL Cadet S Ali C Epstein (1994) ArticleTitleInvolvement of oxygen-based radicals in methamphetamine-induced neurotoxicity: evidence from the use of CuZnSOD transgenic mice Ann NY Acad Sci 738 388–391 Occurrence Handle7530424 Occurrence Handle1:CAS:528:DyaK28XjvV2ksLw%3D Occurrence Handle10.1111/j.1749-6632.1994.tb21827.x

    Article  PubMed  CAS  Google Scholar 

  • W Cao JM Carney A Duchon RA Floyd M Chevion (1988) ArticleTitleOxygen free radical involvement in ischemia and reperfusion injury to brain Neurosci Lett 88 233–238 Occurrence Handle3380359 Occurrence Handle1:CAS:528:DyaL1cXkt1WitLw%3D

    PubMed  CAS  Google Scholar 

  • N Chen ME Reith (2000) ArticleTitleStructure and function of the dopamine transporter Eur J Pharmacol 405 329–339 Occurrence Handle11033338 Occurrence Handle1:CAS:528:DC%2BD3cXnt1Sitbo%3D

    PubMed  CAS  Google Scholar 

  • CC Chiueh H Miyake MT Peng (1993) ArticleTitleRole of dopamine autoxidation, hydroxyl radical generation, and calcium overload in underlying mechanisms involved in MPTP-induced parkinsonism Adv Neurol 60 251–258 Occurrence Handle8380519 Occurrence Handle1:CAS:528:DyaK3sXksVKgs74%3D

    PubMed  CAS  Google Scholar 

  • CC Chiueh SJ Huang DL Murphy (1994) ArticleTitleSuppression of hydroxyl radical formation by MAO inhibitors: a novel possible neuroprotective mechanism in dopaminergic neurotoxicity J Neural Transm [Suppl] 41 189–196 Occurrence Handle1:CAS:528:DyaK2MXlsFals74%3D

    CAS  Google Scholar 

  • CC Chiueh R-M Wu KP Mohanakumar LM Sternberger G Krishna T Obata DL Murphy (1994) ArticleTitleIn vivo generation of hydroxyl radicals and MPTP-induced dopaminergic toxicity in the basal ganglia Ann NY Acad Sci 738 25–36 Occurrence Handle7832434 Occurrence Handle1:CAS:528:DyaK28XjvV2lurw%3D Occurrence Handle10.1111/j.1749-6632.1994.tb21786.x

    Article  PubMed  CAS  Google Scholar 

  • L Comini T Bachetti G Gaia E Pasini L Agnoletti P Pepi C Ceconi S Curello R Ferrari (1996) ArticleTitleAorta and skeletal muscle NO synthase expression in experimental heart failure J Mol Cell Cardiol 28 2241–2248 Occurrence Handle8938577 Occurrence Handle1:CAS:528:DyaK28XmvFyjtr0%3D

    PubMed  CAS  Google Scholar 

  • C Cosi M Marien (1999) ArticleTitleImplication of poly (ADP-ribose) polymerase (PARP) in neurodegeneration and brain energy metabolism. Decreases in mouse brain NAD+ and ATP caused by MPTP are prevented by the PARP inhibitor benzamide Ann NY Acad Sci 890 227–239 Occurrence Handle10668429 Occurrence Handle1:CAS:528:DC%2BD3cXnsVGitg%3D%3D

    PubMed  CAS  Google Scholar 

  • JF Cubells S Rayport G Rajendran D Sulzer (1994) ArticleTitleMethamphetamine neurotoxicity involves vacuolation of endocytic organelles and dopamine-dependent intracellular oxidative stress J Neurosci 14 2260–2271 Occurrence Handle8158268 Occurrence Handle1:CAS:528:DyaK2cXkslemsb4%3D

    PubMed  CAS  Google Scholar 

  • V Darley-Usmar H Wiseman B Halliwell (1995) ArticleTitleNitric oxide and oxygen radicals: a question of balance FEBS Lett 369 131–135 Occurrence Handle7649244 Occurrence Handle1:CAS:528:DyaK2MXnslyiu74%3D

    PubMed  CAS  Google Scholar 

  • C Davidson AJ Gow TH Lee EH Ellinwood (2001) ArticleTitleMethamphetamine neurotoxicity: necrotic and apoptotic mechanisms and relevance to human abuse and treatment Brain Res Brain Res Rev 36 1–22 Occurrence Handle11516769 Occurrence Handle1:CAS:528:DC%2BD3MXmtFSqu7Y%3D

    PubMed  CAS  Google Scholar 

  • VL Dawson TM Dawson DA Bartley GR Uhl SH Snyder (1993) ArticleTitleMechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures J Neurosci 13 2651–2661 Occurrence Handle7684776 Occurrence Handle1:CAS:528:DyaK3sXltFSktLg%3D

    PubMed  CAS  Google Scholar 

  • A Denicola R Radi (2005) ArticleTitlePeroxynitrite and drug-dependent toxicity Toxicology 208 273–288 Occurrence Handle15691591 Occurrence Handle1:CAS:528:DC%2BD2MXhtVOrsLY%3D

    PubMed  CAS  Google Scholar 

  • DA Di Monte JE Royland A Anderson K Castagnoli N Castagnoli SuffixJr JW Langston (1997) ArticleTitleInhibition of monoamine oxidase contributes to the protective effect of 7-nitroindazole against MPTP neurotoxicity J Neurochem 69 1771–1773 Occurrence Handle9326308 Occurrence Handle1:CAS:528:DyaK2sXmsVCkt70%3D Occurrence Handle10.1046/j.1471-4159.1997.69041771.x

    Article  PubMed  CAS  Google Scholar 

  • DA Di Monte JE Royland MW Jakowec JW Langston (1996) ArticleTitleRole of nitric oxide in methamphetamine neurotoxicity: protection by 7-nitroindazole, an inhibitor of neuronal nitric oxide synthase J Neurochem 67 2443–2450 Occurrence Handle8931477 Occurrence Handle1:CAS:528:DyaK28Xnt1Wjs78%3D Occurrence Handle10.1046/j.1471-4159.1996.67062443.x

    Article  PubMed  CAS  Google Scholar 

  • SB Dunnett A Bjorklund (1999) ArticleTitleProspects for new restorative and neuroprotective treatments in Parkinson’s disease Nature 399 A32–A39 Occurrence Handle10392578 Occurrence Handle1:CAS:528:DyaK1MXktlejsbg%3D

    PubMed  CAS  Google Scholar 

  • F Facchinetti R Dall’Olio E Ciani M Sparapani M Virgili A Contestabile (1994) ArticleTitleLong-lasting effects of chronic neonatal blockade of N-methyl-D-aspartate receptor through the competitive antagonist CGP 39551 in rats Neuroscience 60 343–353 Occurrence Handle7915409 Occurrence Handle1:CAS:528:DyaK2cXlsVyku7Y%3D

    PubMed  CAS  Google Scholar 

  • RJ Ferrante P Hantraye E Brouillet MF Beal (1999) ArticleTitleIncreased nitrotyrosine immunoreactivity in substantia nigra neurons in MPTP treated baboons is blocked by inhibition of neuronal nitric oxide synthase Brain Res 823 177–182 Occurrence Handle10095024 Occurrence Handle1:CAS:528:DyaK1MXhvVCntL4%3D

    PubMed  CAS  Google Scholar 

  • AE Fleckenstein RR Metzger ML Beyeler JW Gibb GR Hanson (1997) ArticleTitleOxygen radicals diminish dopamine transporter function in rat striatum Eur J Pharmacol 334 111–114 Occurrence Handle9346337 Occurrence Handle1:CAS:528:DyaK2sXmsVKmsLc%3D

    PubMed  CAS  Google Scholar 

  • RA Floyd JJ Watson PK Wong (1984) ArticleTitleSensitive assay of hydroxyl free radical Formation utilizing high pressure liquid chromatography with electrochemical detection of phenol and salicylate hydroxylation products J Biochem Biophys Methods 10 221–235 Occurrence Handle6530510 Occurrence Handle1:CAS:528:DyaL2MXhvVWksbw%3D

    PubMed  CAS  Google Scholar 

  • B Fornstedt A Burn E Rosengren A Carlson (1989) ArticleTitleThe apparent autooxidation rate of catechols in dopamine-rich regions of human brains increases with the degree of depigmentation of substantia nigra J Neural Tansm [P-D Sect] 1 279–295 Occurrence Handle1:STN:280:DyaK3c%2FovVOntg%3D%3D

    CAS  Google Scholar 

  • B Fornstedt E Pileblad A Carlsson (1990) ArticleTitleIn vivo autoxidation of dopamine in guinea pig striatum increases with age J Neurochem 55 655–659 Occurrence Handle2370552 Occurrence Handle1:CAS:528:DyaK3cXlsVGkt70%3D

    PubMed  CAS  Google Scholar 

  • RR Gainetdinov F Fumagalli SR Jones MG Caron (1997) ArticleTitleDopamine transporter is required for in vivo MPTP neurotoxicity: evidence from mice lacking the transporter J Neurochem 69 IssueID3 1322–1325 Occurrence Handle9282960 Occurrence Handle1:CAS:528:DyaK2sXls1Chu7w%3D Occurrence Handle10.1046/j.1471-4159.1997.69031322.x

    Article  PubMed  CAS  Google Scholar 

  • M Gerlach D Ben-Shachar P Riederer MBH Youdim (1994) ArticleTitleAltered brain metabolism of iron as a cause of neurodegenerative diseases? J Neurochem 63 793–807 Occurrence Handle7519659 Occurrence Handle1:CAS:528:DyaK2cXlsFCgtLo%3D Occurrence Handle10.1046/j.1471-4159.1994.63030793.x

    Article  PubMed  CAS  Google Scholar 

  • RA Gonzalez-Polo G Soler A Rodriguezmartin JM Moran JM Fuentes (2004) ArticleTitleProtection against MPP+ neurotoxicity in cerebellar granule cells by antioxidants Cell Biol Int 28 373–380 Occurrence Handle15193280 Occurrence Handle1:CAS:528:DC%2BD2cXkvVCks74%3D

    PubMed  CAS  Google Scholar 

  • PF Good A Hsu P Werner DP Perl CW Olanow (1998) ArticleTitleProtein nitration in Parkinson’s disease J Neuropathol Exp Neurol 57 338–342 Occurrence Handle9600227 Occurrence Handle1:STN:280:DyaK1c3mtVymtg%3D%3D

    PubMed  CAS  Google Scholar 

  • PF Good P Werner A Hsu CW Olanow DP Perl (1996) ArticleTitleEvidence of neuronal oxidative damage in Alzheimer’s disease Am J Pathol 149 21–28 Occurrence Handle8686745 Occurrence Handle1:STN:280:DyaK283nsFGntw%3D%3D

    PubMed  CAS  Google Scholar 

  • DC Graham (1984) ArticleTitleCatecholamine toxicity: A proposal for the molecular pathogenesis of manganese neurotoxicity and Parkinson’s disease Neurotoxicology 5 83–96 Occurrence Handle6538951 Occurrence Handle1:CAS:528:DyaL2cXks1OjtLw%3D

    PubMed  CAS  Google Scholar 

  • M Guttman J Burkholder SJ Kish D Hussey A Wilson J DaSilva S Houle (1997) ArticleTitle[11C]RTI-32 PET studies of the dopamine transporter in early dopa-naive Parkinson’s disease: implications for the symptomatic threshold Neurology 48 1578–1583 Occurrence Handle9191769 Occurrence Handle1:STN:280:DyaK2szjsFWjsQ%3D%3D

    PubMed  CAS  Google Scholar 

  • B Halliwell H Kaur M Ingleman-Sundberg (1991) ArticleTitleHydroxylation of salicylate as an assay for hydroxyl radicals: a cautionary note Free Rad Biol Med 10 439–441 Occurrence Handle1654291 Occurrence Handle1:CAS:528:DyaK38XivFOr

    PubMed  CAS  Google Scholar 

  • GR Hanson JW Gibb RR Metzger JM Kokoshka AE Fleckenstein (1998) ArticleTitleMethamphetamine-induced rapid and reversible reduction in the activities of tryptophan hydroxylase and dopamine transporters: oxidative consequences? Ann NY Acad Sci 844 103–107 Occurrence Handle9668668 Occurrence Handle1:CAS:528:DyaK1cXks12lsrg%3D

    PubMed  CAS  Google Scholar 

  • P Hantraye E Brouillet R Ferrante S Palfi R Dolan RT Matthews MF Beal (1996) ArticleTitleInhibition of neuronal nitric oxide synthase prevents MPTP-induced parkinsonism in baboons Nat Med 2 1017–1021 Occurrence Handle8782460 Occurrence Handle1:CAS:528:DyaK28XlsFenu7w%3D

    PubMed  CAS  Google Scholar 

  • SJ Heales JP Bolanos VC Stewart PS Brookes JM Land JB Clark (1999) ArticleTitleNitric oxide, mitochondria and neurological disease Biochim Biophys Acta 1410 215–228 Occurrence Handle10076028 Occurrence Handle1:STN:280:DyaK1M7nslCksg%3D%3D

    PubMed  CAS  Google Scholar 

  • Y Itzhak JL Martin SF Ali (1999) ArticleTitleMethamphetamine- and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic neurotoxicity in inducible nitric oxide synthase-deficient mice Synapse 34 305–312 Occurrence Handle10529724 Occurrence Handle1:CAS:528:DyaK1MXnt1yrs7s%3D

    PubMed  CAS  Google Scholar 

  • M Jaber S Jones B Giros MG Caron (1997) ArticleTitleThe dopamine transporter: a crucial component regulating dopamine transmission Mov Disord 12 629–633 Occurrence Handle9380041 Occurrence Handle1:STN:280:DyaK1c%2FhslGgtA%3D%3D

    PubMed  CAS  Google Scholar 

  • JA Javitch SH Snyder (1984) ArticleTitleUptake of MPP+ by dopamine neurons explains selectivity of parkinsonism-inducing neurotoxin, MPTP Eur J Pharmacol 106 455–456 Occurrence Handle6335692 Occurrence Handle1:CAS:528:DyaL2MXmtVaksQ%3D%3D

    PubMed  CAS  Google Scholar 

  • JA Javitch RJ D’Amato SM Strittmatter SH Snyder (1985) ArticleTitleParkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity Proc Natl Acad Sci USA 82 2173–2177 Occurrence Handle3872460 Occurrence Handle1:CAS:528:DyaL2MXktVWltbk%3D

    PubMed  CAS  Google Scholar 

  • P Jenner (1998) ArticleTitleOxidative mechanisms in nigral cell death in Parkinson’s disease Mov Disord 13 24–34 Occurrence Handle9613715

    PubMed  Google Scholar 

  • MJ Kaufman BK Madras (1991) ArticleTitleSevere depletion of cocaine recognition sites associated with the dopamine transporter in Parkinson’s-diseased striatum Synapse 9 43–49 Occurrence Handle1796351 Occurrence Handle1:CAS:528:DyaK3MXmsFeht7o%3D

    PubMed  CAS  Google Scholar 

  • MR Kilbourn K Kuszpit P Sherman (2000) ArticleTitleRapid and differential losses of in vivo dopamine transporter (DAT) and vesicular monoamine transporter (VMAT2) radioligand binding in MPTP-treated mice Synapse 35 250–255 Occurrence Handle10657034 Occurrence Handle1:CAS:528:DC%2BD3cXhtF2htLw%3D

    PubMed  CAS  Google Scholar 

  • P Klivenyi OA Andreassen RJ Ferrante A Dedeoglu G Mueller E Lancelot M Bogdanov JK Andersen D Jiang MF Beal (2000) ArticleTitleMice deficient in cellular glutathione peroxidase show increased vulnerability to malonate, 3-nitropropionic acid, and 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine J Neurosci 20 1–7 Occurrence Handle10627575 Occurrence Handle1:CAS:528:DC%2BD3cXhtF2itb4%3D

    PubMed  CAS  Google Scholar 

  • RG Knowles M Palacios RM Palmer S Moncada (1989) ArticleTitleFormation of nitric oxide from L-arginine in the central nervous system: a transduction mechanism for stimulation of the soluble guanylate cyclase Proc Natl Acad Sci USA 86 5159–5162 Occurrence Handle2567995 Occurrence Handle1:CAS:528:DyaL1MXkslelurc%3D

    PubMed  CAS  Google Scholar 

  • IJ Kopin SP Markey (1988) ArticleTitleMPTP toxicity: implications for research in Parkinson’s disease Annu Rev Neurosci 11 81–96 Occurrence Handle3129982 Occurrence Handle1:CAS:528:DyaL1cXhvVWnu7w%3D

    PubMed  CAS  Google Scholar 

  • WH Koppenol JJ Moreno WA Pryor H Ischiropoulos JS Beckman (1992) ArticleTitlePeroxynitrite, a cloaked oxidant formed by nitric oxide and superoxide Chem Res Toxicol 5 834–842 Occurrence Handle1336991 Occurrence Handle1:CAS:528:DyaK38Xmt1Oqs7w%3D

    PubMed  CAS  Google Scholar 

  • JW Langston (1985) ArticleTitleMPTP neurotoxicity: an overview and characterization of phases of toxicity Life Sci 36 201–206 Occurrence Handle2857048 Occurrence Handle1:CAS:528:DyaL2MXntlGmtw%3D%3D

    PubMed  CAS  Google Scholar 

  • JW Langston I Irwin EB Langston LS Forno (1984) ArticleTitle1-Methyl-4-phenylpyridinium ion (MPP+): identification of a metabolite of MPTP, a toxin selective to the substantia nigra Neurosci Lett 48 87–92 Occurrence Handle6332288 Occurrence Handle1:CAS:528:DyaL2cXlt1Cgt7c%3D Occurrence Handle10.1016/0304-3940(84)90293-3

    Article  PubMed  CAS  Google Scholar 

  • HC Lin BH Kang CS Wong SP Mao FJ Wan (1999) ArticleTitleSystemic administration of D-amphetamine induced a delayed production of nitric oxide in the striatum of rats Neurosci Lett 276 141–144 Occurrence Handle10612625 Occurrence Handle1:CAS:528:DyaK1MXnsVKmtb0%3D

    PubMed  CAS  Google Scholar 

  • J Lotharius KL O’Malley (2000) ArticleTitleThe parkinsonism-inducing drug 1-methyl-4-phenylpyridinium triggers intracellular dopamine oxidation. A novel mechanism of toxicity J Biol Chem 275 38581–38588 Occurrence Handle10969076 Occurrence Handle1:CAS:528:DC%2BD3cXoslymt7c%3D

    PubMed  CAS  Google Scholar 

  • KU Malik E Sehic (1990) ArticleTitleProstaglandins and the release of the adrenergic transmitter Ann NY Acad Sci 604 222–236 Occurrence Handle1977349 Occurrence Handle1:CAS:528:DyaK3MXksVals7k%3D

    PubMed  CAS  Google Scholar 

  • K Marek R Innis C van Dyck B Fussell M Early S Eberly D Oakes J Seibyl (2001) ArticleTitle[123I]beta-CIT SPECT imaging assessment of the rate of Parkinson’s disease progression Neurology 57 2089–2094 Occurrence Handle11739831 Occurrence Handle1:STN:280:DC%2BD3MjgtFCrsA%3D%3D

    PubMed  CAS  Google Scholar 

  • SP Markey JN Johannessen CC Chiueh RS Burns MA Herkenham (1984) ArticleTitleIntraneuronal generation of a pyridinium metabolite may cause drug-induced parkinsonism Nature 311 464–467 Occurrence Handle6332988 Occurrence Handle1:CAS:528:DyaL2cXlvV2hsLY%3D

    PubMed  CAS  Google Scholar 

  • RT Matthews L Yang MF Beal (1997) ArticleTitleS-Methylthiocitrulline, a neuronal nitric oxide synthase inhibitor, protects against malonate and MPTP neurotoxicity Exp Neurol 143 282–286 Occurrence Handle9056390 Occurrence Handle1:CAS:528:DyaK2sXit1art7g%3D

    PubMed  CAS  Google Scholar 

  • H Miyake CC Chiueh (1989) ArticleTitleEffects of MPP+ on the release of serotonin and 5-hydroxyindole acetic acid from rat striatum in vivo Eur J Pharmacol 166 49–55 Occurrence Handle2478372 Occurrence Handle1:CAS:528:DyaL1MXlt1ynurg%3D

    PubMed  CAS  Google Scholar 

  • Y Mizuno N Hattori H Matsumine (1998) ArticleTitleNeurochemical and neurogenetic correlates of Parkinson’s disease J Neurochem 71 893–902 Occurrence Handle9721714 Occurrence Handle1:CAS:528:DyaK1cXls1Khsbo%3D Occurrence Handle10.1046/j.1471-4159.1998.71030893.x

    Article  PubMed  CAS  Google Scholar 

  • H Mochizuki K Goto H Mori Y Mizuno (1996) ArticleTitleHistochemical detection of apoptosis in Parkinson’s disease J Neurol Sci 137 120–123 Occurrence Handle8782165 Occurrence Handle1:STN:280:DyaK28znsFyktA%3D%3D

    PubMed  CAS  Google Scholar 

  • KP Mohanakumar I Hanbauer CC Chiueh (1998) ArticleTitleNeuroprotection by nitric oxide against hydroxyl radical-induced nigral neurotoxicity J Chem Neuroanat 14 195–205 Occurrence Handle9704898 Occurrence Handle1:CAS:528:DyaK1cXlslCkt78%3D

    PubMed  CAS  Google Scholar 

  • KP Mohanakumar HW Steinbusch (1998) ArticleTitleHydroxyl radicals and nitric oxide in neurotoxicity and neuroprotection J Chem Neuroanat 14 125–127 Occurrence Handle9704890 Occurrence Handle1:CAS:528:DyaK1cXlslCksbk%3D

    PubMed  CAS  Google Scholar 

  • JA Molina FJ Jimenez-Jimenez M Orti-Pareja JA Navarro (1998) ArticleTitleThe role of nitric oxide in neurodegeneration. Potential for pharmacological intervention Drugs Aging 12 251–259 Occurrence Handle9571390 Occurrence Handle1:CAS:528:DyaK1cXivVChtr8%3D

    PubMed  CAS  Google Scholar 

  • T Nagatsu H Ichinose (1999) ArticleTitleMolecular biology of catecholamine-related enzymes in relation to Parkinson’s disease Cell Mol Neurobiol 19 57–66 Occurrence Handle10079965 Occurrence Handle1:CAS:528:DyaK1MXhsFSitL4%3D

    PubMed  CAS  Google Scholar 

  • T Obata (1999) ArticleTitleReserpine prevents hydroxyl radical formation by MPP+ in rat striatum Brain Res 828 68–73 Occurrence Handle10320725 Occurrence Handle1:CAS:528:DyaK1MXivFeiur0%3D

    PubMed  CAS  Google Scholar 

  • T Obata (2002a) ArticleTitleDopamine efflux by MPTP and hydroxyl radical generation J Neural Transm 109 1159–1180 Occurrence Handle1:CAS:528:DC%2BD38Xpsleit7o%3D

    CAS  Google Scholar 

  • T Obata (2002b) ArticleTitleNitric oxide and depolarization induces hydroxyl radical generation Jpn J Pharmcol 88 1–5 Occurrence Handle1:CAS:528:DC%2BD38XpsFanuw%3D%3D

    CAS  Google Scholar 

  • T Obata (2002c) ArticleTitleEnvironmental estrogen-like chemicals and hydroxyl radicals induced by MPTP in the striatum: a review Neurochem Res 27 423–431 Occurrence Handle1:CAS:528:DC%2BD38XksVGmuro%3D

    CAS  Google Scholar 

  • T Obata (2003) ArticleTitleCalcium overload enhances hydroxyl radical generation by 1-methyl-4-phenylpyridinium ion (MPP+) in rat striatum Brain Res 965 287–289 Occurrence Handle12591149 Occurrence Handle1:CAS:528:DC%2BD3sXht1Kmsb4%3D

    PubMed  CAS  Google Scholar 

  • T Obata M Aomine Y Yamanaka (2000) ArticleTitlePotassium chloride depolarization enhances MPP+-induced hydroxyl radical generation in the rat striatum Brain Res 852 488–491 Occurrence Handle10678780 Occurrence Handle1:CAS:528:DC%2BD3cXhtVOrurw%3D

    PubMed  CAS  Google Scholar 

  • T Obata CC Chiueh (1992) ArticleTitleIn vivo trapping of hydroxyl free radicals in the striatum utilizing intracranial microdialysis perfusion of salicylate: effects of MPTP, MPDP+ and MPP+ J Neural Transm [Gen Sect] 89 139–145 Occurrence Handle1:CAS:528:DyaK3sXjsVSksQ%3D%3D

    CAS  Google Scholar 

  • T Obata S Kubota (2001) ArticleTitleProtective effect of tamoxifen on 1-methyl-4-phenylpyridine-induced hydroxyl radical generation in the rat striatum Neurosci Lett 308 87–90 Occurrence Handle11457566 Occurrence Handle1:CAS:528:DC%2BD3MXltF2jsr8%3D

    PubMed  CAS  Google Scholar 

  • T Obata Y Yamanaka H Kinemuchi L Oreland (2001) ArticleTitleRelease of dopamine by perfusion with 1-methyl-4-phenylpyridinium ion (MPP+) into the striatum is associated with hydroxyl free radical generation Brain Res 906 170–175 Occurrence Handle11430875 Occurrence Handle1:CAS:528:DC%2BD3MXks1OntLg%3D

    PubMed  CAS  Google Scholar 

  • T Obata Y Yamanaka (2001) ArticleTitleNitric oxide enhances MPP+-induced hydroxyl radical generation via depolarization activated nitric oxide synthase in rat striatum Brain Res 902 223–228 Occurrence Handle11384616 Occurrence Handle1:CAS:528:DC%2BD3MXjvV2qs7k%3D

    PubMed  CAS  Google Scholar 

  • M Oka Y Itoh Y Ukai K Kimura (1999) ArticleTitleBlockade by NS-7, a neuroprotective compound, of both L-type and P/Q-type Ca2+ channels involving depolarization-stimulated nitric oxide synthase activity in primary neuronal culture J Neurochem 72 1315–1322 Occurrence Handle10037505 Occurrence Handle1:CAS:528:DyaK1MXhsFWgtr0%3D

    PubMed  CAS  Google Scholar 

  • CW Olanow WG Tatton (1999) ArticleTitleEtiology and pathogenesis of Parkinson’s disease Ann Rev Neurosci 22 123–144 Occurrence Handle10202534 Occurrence Handle1:CAS:528:DyaK1MXhvFemsro%3D

    PubMed  CAS  Google Scholar 

  • K Osborne H Zhao AW Fuqua (2000) ArticleTitleSelective estrogen receptor modulators: structure, function, and clinical use J Clin Oncol 18 3172–3186 Occurrence Handle10963646 Occurrence Handle1:CAS:528:DC%2BD3cXntVCgsbY%3D

    PubMed  CAS  Google Scholar 

  • K Osuka PJ Feustel AA Mongin BI Tranmer HK Kimelberg (2001) ArticleTitleTamoxifen inhibits nitrotyrosine formation after reversible middle cerebral artery occlusion in the rat J Neurochem 76 1842–1850 Occurrence Handle11259502 Occurrence Handle1:CAS:528:DC%2BD3MXitlSkt7Y%3D

    PubMed  CAS  Google Scholar 

  • N Ozaki D Nakahara N Kaneda K Kiuchi T Okada Y Kasahara T Nagatsu (1987) ArticleTitleAcute effects of 1-methyl-4-phenylpyridinium ion (MPP+) on dopamine and serotonin metabolism in rat striatum as assayed in vivo by a microdialysis technique J Neural Transm 70 241–250 Occurrence Handle3500274 Occurrence Handle1:CAS:528:DyaL1cXjtlektQ%3D%3D

    PubMed  CAS  Google Scholar 

  • RM Palmer DS Ashton S Moncada (1988) ArticleTitleVascular endothelial cells synthesize nitric oxide from L-arginine Nature 333 664–666 Occurrence Handle3131684 Occurrence Handle1:CAS:528:DyaL1cXktlGktb8%3D

    PubMed  CAS  Google Scholar 

  • SU Park JV Ferrer JA Javitch DM Kuhn (2002) ArticleTitlePeroxynitrite inactivates the human dopamine transporter by modification of cysteine 342: potential mechanism of neurotoxicity in dopamine neurons J Neurosci 22 4399–4405 Occurrence Handle12040046 Occurrence Handle1:CAS:528:DC%2BD38XksFWgtbk%3D

    PubMed  CAS  Google Scholar 

  • S Pennathur V Jackson-Lewis S Przedborski JW Heinecke (1999) ArticleTitleMass spectrometric quantification of 3-nitrotyrosine, ortho-tyrosine, and o,o’-dityrosine in brain tissue of 1-methyl-4- phenyl-1,2,3,6-tetrahydropyridine-treated mice, a model of oxidative stress in Parkinson’s disease J Biol Chem 274 34621–34628 Occurrence Handle10574926 Occurrence Handle1:CAS:528:DyaK1MXnvFyrsrs%3D

    PubMed  CAS  Google Scholar 

  • B Pilas T Sarna B Kalyanaraman HM Swartz (1988) ArticleTitleThe effect of melanin on iron associated decomposition of hydrogen peroxide Free Rad Biol Med 4 285–293 Occurrence Handle2834276 Occurrence Handle1:CAS:528:DyaL1cXktF2jsbw%3D

    PubMed  CAS  Google Scholar 

  • SR Powell D Hall (1990) ArticleTitleUse of salicylate as a probe for •OH formation in isolated ischemic rat hearts Free Rad Biol Med 9 133–141 Occurrence Handle2172099 Occurrence Handle1:CAS:528:DyaK3MXlslKkurs%3D

    PubMed  CAS  Google Scholar 

  • S Przedborski V Jackson-Lewis R Yokoyama T Shibata VL Dawson TM Dawson (1996) ArticleTitleRole of neuronal nitric oxide in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity Proc Natl Acad Sci USA 93 4565–4571 Occurrence Handle8643444 Occurrence Handle1:CAS:528:DyaK28XjtVKmurg%3D

    PubMed  CAS  Google Scholar 

  • S Przedborski V Jackson-Lewis (1998) ArticleTitleMechanisms of MPTP toxicity Mov Disord 13 35–38 Occurrence Handle9613716

    PubMed  Google Scholar 

  • R Radi JS Beckman KM Bush BA Freeman (1991) ArticleTitlePeroxynitrite-induced membrane lipid peroxidation: the cytotoxic potential of superoxide and nitric oxide Arch Biochem Biophys 288 481–487 Occurrence Handle1654835 Occurrence Handle1:CAS:528:DyaK3MXksVertrY%3D

    PubMed  CAS  Google Scholar 

  • DM Radzik DA Roston PT Kissinger (1983) ArticleTitleDetermination of hydroxylated aromatic compounds produced via superoxide-dependent formation of hydroxyl radicals by liquid chromatography/electrochemistry Anal Biochem 131 458–464 Occurrence Handle6311054 Occurrence Handle1:CAS:528:DyaL3sXktF2jtbc%3D

    PubMed  CAS  Google Scholar 

  • P Rauhala KP Mohanakumar I Sziraki AM Lin CC Chiueh (1996) ArticleTitleS-nitrosothiols and nitric oxide, but not sodium nitroprusside, protect nigrostriatal dopamine neurons against iron-induced oxidative stress in vivo Synapse 23 58–60 Occurrence Handle8723136 Occurrence Handle1:CAS:528:DyaK28XislajtL4%3D

    PubMed  CAS  Google Scholar 

  • A Renodon JL Boucher MA Sari M Delaforge J Quazzani D Mansuy (1997) ArticleTitleStron inhibition of neuronal nitric oxide synthase by the calmodulin antagonist and anti-estrogen drug tamoxifen Biochem Pharmacol 54 1109–1114 Occurrence Handle9464453 Occurrence Handle1:CAS:528:DyaK2sXntFemtb4%3D

    PubMed  CAS  Google Scholar 

  • P Riederer E Sofic W-D Rausch B Schmidt GP Reynolds K Jellinger MBH Youdim (1989) ArticleTitleTransition metals, ferritin, glutathione, and ascorbic acid in parkinsonian brains J Neurochem 52 515–520 Occurrence Handle2911028 Occurrence Handle1:CAS:528:DyaL1MXhtFals78%3D

    PubMed  CAS  Google Scholar 

  • H Rollema WG Kuhr G Kranenborg J De Vries C Van den Berg (1988) ArticleTitleMPP+-induced efflux of dopamine and lactate from rat striatum have similar time courses as shown by in vivo brain dialysis J Pharmacol Exp Ther 245 858–866 Occurrence Handle2455037 Occurrence Handle1:CAS:528:DyaL1cXks1ynt74%3D

    PubMed  CAS  Google Scholar 

  • S Rose JG Hindmarsh P Jenner (1999) ArticleTitleNeuronal nitric oxide synthase inhibition reduces MPP+-evoked hydroxyl radical formation but not dopamine efflux in rat striatum J Neural Transm 106 477–486 Occurrence Handle10443551 Occurrence Handle1:CAS:528:DyaK1MXltVKltL0%3D

    PubMed  CAS  Google Scholar 

  • V Sandoval EL Riddle YV Ugarte GR Hanson AE Fleckenstein (2001) ArticleTitleMethamphetamine-induced rapid and reversible changes in dopamine transporter function: an in vitro model J Neurosci 21 1413–1419 Occurrence Handle11160413 Occurrence Handle1:CAS:528:DC%2BD3MXhtFertro%3D

    PubMed  CAS  Google Scholar 

  • S Schinelli A Zuddas IJ Kopin JL Barker U di Porzio (1988) ArticleTitle1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine metabolism and 1-methyl-4-phenylpyridinium uptake in dissociated cell cultures from the embryonic mesencephalon J Neurochem 50 1900–1907 Occurrence Handle3259619 Occurrence Handle1:CAS:528:DyaL1cXktlegur8%3D

    PubMed  CAS  Google Scholar 

  • N Schmidt B Ferger (2001) ArticleTitleNeurochemical findings in the MPTP model of Parkinson’s disease J Neural Transm 108 1263–1282 Occurrence Handle11768626 Occurrence Handle1:CAS:528:DC%2BD38XhsVSqt7g%3D

    PubMed  CAS  Google Scholar 

  • JB Schulz RT Matthews T Klockgether J Dichgans MF Beal (1997) ArticleTitleThe role of mitochondrial dysfunction and neuronal nitric oxide in animal models of neurodegenerative diseases Mol Cell Biochem 174 193–197 Occurrence Handle9309687 Occurrence Handle1:CAS:528:DyaK2sXmt1eqtbw%3D

    PubMed  CAS  Google Scholar 

  • JB Schulz RT Matthews MM Muqit SE Browne MF Beal (1995) ArticleTitleInhibition of neuronal nitric oxide synthase by 7-nitroindazole protects against MPTP-induced neurotoxicity in mice J Neurochem 64 936–939 Occurrence Handle7530297 Occurrence Handle1:CAS:528:DyaK2MXjtFymtLs%3D Occurrence Handle10.1046/j.1471-4159.1995.64020936.x

    Article  PubMed  CAS  Google Scholar 

  • X Shi A Lenhart Y Mao (1994) ArticleTitleESR spin trapping investigation on peroxynitrite decomposition: no evidence for hydroxyl radical production Biochem Biophys Res Commun 203 1515–1521 Occurrence Handle7945300 Occurrence Handle1:CAS:528:DyaK2cXmt1ert7Y%3D

    PubMed  CAS  Google Scholar 

  • CA Singer KL Rogers TM Strickland DM Dorsa (1996) ArticleTitleEstrogen protects primary cortical neurons from glutamate toxicity Neurosci Lett 212 13–16 Occurrence Handle8823751 Occurrence Handle1:CAS:528:DyaK28XktlSitLk%3D

    PubMed  CAS  Google Scholar 

  • TP Singer JI Salach N Castagnoli SuffixJr A Trevor (1986) ArticleTitleInteractions of the neurotoxic amine 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine with monoamine oxidases Biochem J 235 785–789 Occurrence Handle3489461 Occurrence Handle1:CAS:528:DyaL28Xit1Shurc%3D

    PubMed  CAS  Google Scholar 

  • TS Smith JP Bennett (1997) ArticleTitleMitochondrial toxins in models of neurodegenerative diseases. I. In vivo brain hydroxyl radical production during systemic MPTP treatment or following microdialysis infusion of methylpyridinium or azide ions Brain Res 765 183–188 Occurrence Handle9313890 Occurrence Handle1:CAS:528:DyaK2sXks12nsL4%3D

    PubMed  CAS  Google Scholar 

  • MB Spina G Cohen (1989) ArticleTitleDopamine turnover and glutathione oxidation: implications for Parkinson disease Proc Natl Acad Sci USA 86 1398–1400 Occurrence Handle2919185 Occurrence Handle1:CAS:528:DyaL1MXhtleju7o%3D

    PubMed  CAS  Google Scholar 

  • D Sulzer TK Chen YY Lau H Kristensen S Rayport A Ewing (1995) ArticleTitleAmphetamine redistributes dopamine from synaptic vesicles to the cytosol and promotes reverse transport J Neurosci 15 4102–4108 Occurrence Handle7751968 Occurrence Handle1:CAS:528:DyaK2MXls1aitrg%3D

    PubMed  CAS  Google Scholar 

  • CJ Sun JN Johannessen W Gessner I Namura W Singhaniyom A Brossi CC Chiueh (1988) ArticleTitleNeurotoxic damage to the nigrostriatal system in rats following intranigral administration of MPDP+ and MPP+ J Neural Transm [Gen Sect] 74 75–86 Occurrence Handle1:STN:280:DyaL1M7nslSksA%3D%3D

    CAS  Google Scholar 

  • N Takahashi LL Miner I Sora H Ujike RS Revay V Kostic V Jackson-Lewis S Przedborski GR Uhl (1997) ArticleTitleVMAT2 knockout mice: heterozygotes display reduced amphetamine-conditioned reward, enhanced amphetamine locomotion, and enhanced MPTP toxicity Proc Natl Acad Sci USA 94 9938–9943 Occurrence Handle9275230 Occurrence Handle1:CAS:528:DyaK2sXlvVWnt7c%3D

    PubMed  CAS  Google Scholar 

  • S Tatsumi Y Itoh FH Ma H Higashira Y Ukai Y Yoshikuni K Kimura (1998) ArticleTitleInhibition of depolarization-induced nitric oxide synthase activation by NS-7, a phenylpyrimidine derivative, in primary neuronal culture J Neurochem 70 59–65 Occurrence Handle9422347 Occurrence Handle1:CAS:528:DyaK1cXmtFyq Occurrence Handle10.1046/j.1471-4159.1998.70010059.x

    Article  PubMed  CAS  Google Scholar 

  • K Tsuchiya Y Takiguchi M Okamoto Y Izawa Y Kanematsu M Yoshizumi T Tamaki (2004) ArticleTitleMalfunction of vascular control in lifestyle-related diseases: formation of systemic hemoglobin-nitric oxide complex (HbNO) from dietary nitrite J Pharmacol Sci 96 395–400 Occurrence Handle15599101 Occurrence Handle1:CAS:528:DC%2BD2MXisFGmtg%3D%3D

    PubMed  CAS  Google Scholar 

  • R Varin P Mulder V Richard F Tamion C Devaux JP Henry F Lallemand G Lerebours C Thuillez (1999) ArticleTitleExercise improves flow-mediated vasodilatation of skeletal muscle arteries in rats with chronic heart failure. Role of nitric oxide, prostanoids, and oxidant stress Circulation 99 2951–2957 Occurrence Handle10359741 Occurrence Handle1:CAS:528:DyaK1MXjvFKgsL4%3D

    PubMed  CAS  Google Scholar 

  • A Varrone KL Marek D Jennings RB Innis JP Seibyl (2001) ArticleTitle[(123)I]beta-CIT SPECT imaging demonstrates reduced density of striatal dopamine transporters in Parkinson’s disease and multiple system atrophy Mov Disord 16 1023–1032 Occurrence Handle11748733 Occurrence Handle1:STN:280:DC%2BD3MnpvFCisA%3D%3D

    PubMed  CAS  Google Scholar 

  • L Ver Donck M Borgers (1991) ArticleTitleMyocardial protection by R 56865: a new principle based on prevention of ion channel pathology Am J Physiol 266 H903–H908

    Google Scholar 

  • AS Vidwans S Kim DO Coffin DA Wink SJ Hewett (1999) ArticleTitleAnalysis of the neuroprotective effects of various nitric oxide donor compounds in murine mixed cortical cell culture J Neurochem 72 1843–1852 Occurrence Handle10217260 Occurrence Handle1:CAS:528:DyaK1MXis12lsbw%3D

    PubMed  CAS  Google Scholar 

  • A Virmani F Gaetani S Imam Z Binienda S Ali (2003) ArticleTitlePossible mechanism for the Neuroprotective effects of L-carnitine on methamphetamine-evoked neurotoxicity Ann NY Acad Sci 993 197–207 Occurrence Handle12853314 Occurrence Handle1:CAS:528:DC%2BD3sXmtVajs7s%3D Occurrence Handle10.1111/j.1749-6632.2003.tb07530.x

    Article  PubMed  CAS  Google Scholar 

  • H Wang M Shimoji SW Yu TM Dawson VL Dawson (2003) ArticleTitleApoptosis inducing factor and PARP-mediated injury in the MPTP mouse model of Parkinson’s disease Ann NY Acad Sci 991 132–139 Occurrence Handle12846982 Occurrence Handle1:CAS:528:DC%2BD3sXmtVCku7w%3D Occurrence Handle10.1111/j.1749-6632.2003.tb07471.x

    Article  PubMed  CAS  Google Scholar 

  • H Wiseman M Cannon HRV Arnstein DJ Barlow (1992) ArticleTitleThe structural mimicry of membrane sterols by tamoxifen: evidence from cholesterol coefficients and molecular-modelling for its action as a membrane anti-oxidant and an anti-cancer agent Biochim Biophys Acta 1138 197–202 Occurrence Handle1547281 Occurrence Handle1:CAS:528:DyaK38XhvVyjs7c%3D

    PubMed  CAS  Google Scholar 

  • H Wiseman M Cannon HR Arnstein B Halliwell (1993) ArticleTitleEnhancement by tamoxifen of the membrane antioxidant action of the yeast membrane sterol ergosterol: relevance to the antiyeast and anticancer action of tamoxifen Biochim Biophys Acta 1181 201–216 Occurrence Handle8318548 Occurrence Handle1:CAS:528:DyaK3sXmtFKrurc%3D

    PubMed  CAS  Google Scholar 

  • KY Xu DL Huso TM Dawson DS Bredt LC Becker (1999) ArticleTitleNitric oxide synthase in cardiac sarcoplasmic reticulum Proc Natl Acad Sci USA 86 657–662

    Google Scholar 

  • BK Yamamoto MA Cooperman (1994) ArticleTitleDifferential effects of chronic antipsychotic drug treatment on extracellular glutamate and dopamine concentrations J Neurosci 14 4159–4166 Occurrence Handle7913120 Occurrence Handle1:CAS:528:DyaK2cXlvFGlsLk%3D

    PubMed  CAS  Google Scholar 

  • JL Zweier P Wang A Samouilov P Kuppusamy (1995) ArticleTitleEnzyme-independent formation of nitric oxide in biological tissues Nature Med 1 804–809 Occurrence Handle7585184 Occurrence Handle1:CAS:528:DyaK2MXnt1ynu7g%3D

    PubMed  CAS  Google Scholar 

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  1. Department of Analytical Chemistry, Ohu University School of Pharmaceutical Sciences, Koriyama, Fukushima, Japan

    T. Obata

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Obata, T. Nitric oxide and MPP+-induced hydroxyl radical generation. J Neural Transm 113, 1131–1144 (2006). https://doi.org/10.1007/s00702-005-0415-0

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