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Apoptosis-related genes change their expression with age and hearing loss in the mouse cochlea

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Abstract

To understand possible causative roles of apoptosis gene regulation in age-related hearing loss (presbycusis), apoptotic gene expression patterns in the CBA mouse cochlea of four different age and hearing loss groups were compared, using GeneChip and real-time (qPCR) microarrays. GeneChip transcriptional expression patterns of 318 apoptosis-related genes were analyzed. Thirty eight probes (35 genes) showed significant differences in expression. The significant gene families include Caspases, B-cell leukemia/lymphoma2 family, P53, Calpains, Mitogen activated protein kinase family, Jun oncogene, Nuclear factor of kappa light chain gene enhancer in B-cells inhibitor-related and tumor necrosis factor-related genes. The GeneChip results of 31 genes were validated using the new TaqMan® Low Density Array (TLDA). Eight genes showed highly correlated results with the GeneChip data. These genes are: activating transcription factor3, B-cell leukemia/lymphoma2, Bcl2-like1, caspase4 apoptosis-related cysteine protease 4, Calpain2, dual specificity phosphatase9, tumor necrosis factor receptor superfamily member12a, and Tumor necrosis factor superfamily member13b, suggesting they may play critical roles in inner ear aging.

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Acknowledgements

The research was funded by NIH Grant P01 AG09524 from the Nat. Inst. on Aging, and P30 DC05409 from the Nat. Inst. on Deafness & Comm. Disorders.

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Authors and Affiliations

  1. Department of Physiology, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, NSW, 2052, Australia

    Sherif F. Tadros

  2. International Center for Hearing & Speech Research, National Technical Institute for the Deaf, Rochester Institute of Technology, 52 Lomb Memorial Drive, Rochester, NY, 14623, USA

    Mary D’Souza, Xiaoxia Zhu & Robert D. Frisina

  3. Department of Otolaryngology, University of Rochester School of Medicine & Dentistry, 601 Elmwood Avenue, Rochester, NY, 14642-8629, USA

    Mary D’Souza, Xiaoxia Zhu & Robert D. Frisina

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  1. Sherif F. Tadros
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  2. Mary D’Souza
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  3. Xiaoxia Zhu
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  4. Robert D. Frisina
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Correspondence to Robert D. Frisina.

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Tadros, S.F., D’Souza, M., Zhu, X. et al. Apoptosis-related genes change their expression with age and hearing loss in the mouse cochlea. Apoptosis 13, 1303–1321 (2008). https://doi.org/10.1007/s10495-008-0266-x

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