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Mouse b-wave mutants

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Abstract

The b-wave is a major component of the electroretinogram that reflects the activity of depolarizing bipolar cells (DBCs). The b-wave is used diagnostically to identify patients with defects in DBC signaling or in transmission from photoreceptors to DBCs. In mouse models, an abnormal b-wave has been used to demonstrate a critical role of a particular protein in the release of glutamate from photoreceptor terminals, in establishing the structure of the photoreceptor-to-DBC synapse, in DBC signal transduction, and also in DBC development, survival, or metabolic support. The purpose of this review is to summarize these models and how they have advanced our understanding of outer retinal function.

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Acknowledgments

Work in the author’s laboratories has been supported by grants from the Department of Veterans Affairs, National Institutes of Health, a Foundation Fighting Blindness Center Grant to the Cole Eye Institute, and unrestricted grants from Research to Prevent Blindness to the Departments of Ophthalmology of Emory University and the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University.

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Authors and Affiliations

  1. Rehabilitation Research and Development Center of Excellence, Atlanta VA Medical Center, 1670 Clairmont Road, Decatur, GA, 30033, USA

    Machelle T. Pardue

  2. Department of Ophthalmology, Emory University School of Medicine, 1365B Clifton Road NE, Atlanta, GA, 30322, USA

    Machelle T. Pardue

  3. Research Service (151W), Louis Stokes Cleveland VA Medical Center, 10701 East Boulevard, Cleveland, OH, 44106, USA

    Neal S. Peachey

  4. Cole Eye Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA

    Neal S. Peachey

  5. Department of Ophthalmology, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, 9500 Euclid Avenue, Cleveland, OH, 44195, USA

    Neal S. Peachey

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  1. Machelle T. Pardue
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Correspondence to Neal S. Peachey.

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Pardue, M.T., Peachey, N.S. Mouse b-wave mutants. Doc Ophthalmol 128, 77–89 (2014). https://doi.org/10.1007/s10633-013-9424-8

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