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STDP rule endowed with the BCM sliding threshold accounts for hippocampal heterosynaptic plasticity

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Abstract

We have combined the nearest neighbour additive spike-timing-dependent plasticity (STDP) rule with the Bienenstock, Cooper and Munro (BCM) sliding modification threshold in a computational model of heterosynaptic plasticity in the hippocampal dentate gyrus. As a result we can reproduce (1) homosynaptic long-term potentiation of the tetanized input, and (2) heterosynaptic long-term depression of the untetanized input, as observed in real experiments.

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Authors and Affiliations

  1. Knowledge Engineering & Discovery Research Institute, Auckland University of Technology, Auckland, New Zealand

    Lubica Benuskova

  2. Department of Applied Informatics, Faculty of Mathematics, Physics and Informatics, Comenius University, Bratislava, Slovakia

    Lubica Benuskova

  3. Department of Psychology, University of Otago, Dunedin, New Zealand

    Wickliffe C. Abraham

Authors
  1. Lubica Benuskova
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  2. Wickliffe C. Abraham
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Correspondence to Lubica Benuskova.

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Action Editor: Nicolas Brunel

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Benuskova, L., Abraham, W.C. STDP rule endowed with the BCM sliding threshold accounts for hippocampal heterosynaptic plasticity. J Comput Neurosci 22, 129–133 (2007). https://doi.org/10.1007/s10827-006-0002-x

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  • DOI: https://doi.org/10.1007/s10827-006-0002-x

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