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Mycobacteria-Induced Suppression of Autoimmunity in the Central Nervous System

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Abstract

Mycobacterial suppression of central nervous system (CNS) autoimmunity has been demonstrated in various experimental models, epidemiological studies, and clinical trials. Recent studies have led to an increased understanding of the cellular and molecular interactions involved in the pathogenesis of autoimmune diseases and of mycobacterial immunity. Here, we review some of the mechanisms by which mycobacterial infection might modulate the clinical course of CNS autoimmunity. A more complete understanding of these mechanisms may lead to the development of novel immunotherapeutic tools for treating autoimmune diseases.

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  1. Department of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin, 1300 University Avenue, Madison, WI, 53706, USA

    JangEun Lee, Matyas Sandor, Erika Heninger & Zsuzsanna Fabry

  2. Cellular and Molecular Pathology Program, School of Medicine and Public Health, University of Wisconsin, 1300 University Avenue, Madison, WI, 53706, USA

    JangEun Lee, Matyas Sandor & Zsuzsanna Fabry

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  1. JangEun Lee
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  2. Matyas Sandor
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Lee, J., Sandor, M., Heninger, E. et al. Mycobacteria-Induced Suppression of Autoimmunity in the Central Nervous System. J Neuroimmune Pharmacol 5, 210–219 (2010). https://doi.org/10.1007/s11481-010-9199-6

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