Pharmacological evidence for GABA as the transmitter in granule cell inhibition in the olfactory bulb

doi:10.1016/0006-8993(71)90600-7

Brain Research

Volume 35, Issue 1, 10 December 1971, Pages 137-149

https://doi.org/10.1016/0006-8993(71)90600-7 Get rights and content

Summary

The convulsants picrotoxin and bicuculline block the depressant action of microelectrophoretically administered GABA and strychnine selectively blocks the depressant action of glycine on olfactory bulb mitral cells. The amino acids,d,l-homocysteate (DLH), glutamate, and aspartate, which excite virtually all other central neurons, often inhibited mitral cells and this effect was blocked by Mg²⁺. The depression produced by excitant amino acids is reversed to excitation by picrotoxin and bicuculline. These results are consistent with the proposal that granule cell synaptic inhibition of mitral cells is mediated by GABA. The granule cell inhibition elicited physiologically, however, proved difficult to antagonize with convulsants, but in some cases a degree of antagonism could be demonstrated. The results suggest that GABA may be the inhibitory transmitter released by granule cells.

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Pharmacological evidence for GABA as the transmitter in granule cell inhibition in the olfactory bulb

Summary

Brain Research

Brain Research

Brain Research

Brain Research

Brain Research

Brain Research

Brain Research

Brain Research

Brain Research

Exp. Neurol.

Location of postsynaptic inhibitory synapses on hippocampal pyramids

J. Neurophysiol.

Der Feinbau des Bulbus Olfactorius der Ratte unter besonderer Beru¨cksichtigung der synaptischen Verbindungen

Z. Zellforsch.

The nature of the neuromuscular block produced by magnesium

J. Physiol. (Lond.)

GABA, bicuculline and central inhibition

Nature (Lond.)

GABA and hippocampal inhibition

Brit. J. Pharmacol.

The hyperpolarization of spinal motoneurons by glycine and related amino acids

Exp. Brain Res.

Pharmacological studies upon spinal presynaptic fibres

Exp. Brain Res.

The excitation and depression of spinal neurons by structurally related amino acids

J. Neurochem.

Does strychnine block postsynaptically?

Nature (Lond.)

The Cerebellum as a Neuronal Machine

Recurrent inhibition in the olfactory bulb. I. Effects of antidromic stimulation of the lateral olfactory tract

Neurophysiol.

Effect of magnesium and calcium ions on release of acetylcholine

J. Physiol. (Lond.)