Climbing fiber deafferentation: Its action on Purkinje cell dendritic spines*
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3-Acetylpyridine-induced ataxic-like motor impairments are associated with plastic changes in the Purkinje cells of the rat cerebellum
2021, NeurologiaCitation Excerpt :In agreement with our findings, this could induce an initial activity-dependent decrease of spines24 that, with a putative disruption of intracellular signals in the parallel fiber-dendritic spine synapses due to the lack of endoplasmic reticulum in the spines,25 would impair the organization of motor actions and lead to ataxia. Furthermore, the evidence available and our findings agree with reports showing that tetrodotoxin treatment did not affect spine density at day 7 post-treatment26 but increased it from day 7 to 3 months after 3-AP administration.15 This could occur while parallel fibers are gradually innervating some of the remaining proximal spines, inducing a later increase in their density and competing with climbing fiber sprouting until the atypical parallel fibers decrease, disappear, or come to coexist.27
3-Acetylpyridine neurotoxicity in mice
2017, NeuroToxicologyEvidence for a role of glycoprotein M6a in dendritic spine formation and synaptogenesis
2016, Molecular and Cellular NeuroscienceGait analysis and the cumulative gait index (CGI): Translational tools to assess impairments exhibited by rats with olivocerebellar ataxia
2014, Behavioural Brain ResearchCitation Excerpt :Lesions of the olivocerebellar pathway were induced by the administration of 3-acetylpyridine (3-AP; 70 mg/kg, i.p.) followed by an injection of nicotinamide (300 mg/kg, i.p.) 3.5 h later; chemicals were obtained from Sigma-Aldrich Co. (St. Louis, MO). This injection paradigm has been demonstrated to localize the resulting neurotoxicity primarily to the inferior olive, with weak effects on other brain regions involved in motor control [25–27]. In addition, studies in our laboratory have demonstrated that this injection paradigm leads to the loss of 85% of inferior olivary neurons in rats, and results in impaired performance on the rotorod, balance beam, and in the open field [17].
Neuronal nicotinic receptor agonists improve gait and balance in olivocerebellar ataxia
2013, NeuropharmacologyIntrinsic versus extrinsic determinants during the development of Purkinje cell dendrites
2009, NeuroscienceCitation Excerpt :Nevertheless, these fibers have a more important role, since they are involved in the regulation of the spinogenesis in the proximal dendritic compartment (Sotelo et al., 1975). Experiments performed many years ago allowed us to assume that climbing fibers are essential for this compartmentalization of PC dendrites, since if climbing fibers are removed either during development (Sotelo and Arsenio-Nunes, 1976) or in adult animals (Sotelo et al., 1975), the thorns, stubby spines, disappear, and numerous new long-necked spines, similar to those present in the distal compartment, emerge all along the proximal branches. In the same fashion, in organotypic culture, a system devoid of climbing fibers, PCs bear numerous spines throughout their dendritic tree (Seil et al., 1980; Dusart et al., 1997).
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This research was partially supported by the Institut National de la Santé et de la Recherche Médicale (A.T.P. 6-74-27 No. 20) and by USPHS Research Grant NS-09916 from NINDS.