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2009, Pharmacology and TherapeuticsReversal of ongoing thermal hyperalgesia in mice by a recombinant herpesvirus that encodes human preproenkephalin
2004, Molecular TherapyCitation Excerpt :The reason for this disparity is unknown, but may supply clues as to the mechanism of the antihyperalgesic effect. Both μ and δ opioid receptors are located on presynaptic afferent terminals [21–23], as well as on postsynaptic spinal neurons [23–25]. However, some evidence, including preliminary work in our laboratory using antisense μ opioid receptor HSV vectors, suggests that μ receptors may be presynaptic on C but not Aδ nociceptors [26].
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Attachéde Recherchesàl'INSERM.
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