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Cited by (46)
Deep brain stimulation of the thalamic centromedian-parafascicular nucleus improves behavioural and neuronal traits in a rat model of Tourette
2020, Behavioural Brain ResearchCitation Excerpt :Functional imaging studies in humans demonstrated a significant increase of activity in CM-Pf during processing of attention-related stimuli [47–49]. In line with a direct glutamatergic thalamostriatal connection, electrical stimulation of the CM-Pf in anaesthetized rats and cats induces excitatory activity in striatal regions [50,51]. Altered oscillatory activity and synchrony in different frequency bands reflects compromised neuronal information processing in movement and in neuropsychiatric disorders [52,53].
The Thalamostriatal Systems in Normal and Disease States
2016, Handbook of Behavioral NeuroscienceCitation Excerpt :The functional role(s) of the thalamostriatal system(s) is/are not known. In early electrophysiological studies in anesthetized cats and rats, electrical stimulation of the intralaminar nuclei induced short-latency excitatory postsynaptic potentials (EPSPs) in striatal neurons (Kocsis and Kitai, 1977; Vandermaelen and Kitai, 1980), providing a functional confirmation of the direct thalamostriatal projection that had been described in early anatomical reports using degeneration methods (Powell and Cowan, 1954, 1956; Vogt and Vogt, 1941). Later studies, also performed in anesthetized rats, showed that these thalamic-mediated excitatory responses could be evoked in both MSNs and cholinergic interneurons (Wilson et al., 1983, 1990).
The History of the Basal Ganglia: Cells and Circuits
2016, Handbook of Behavioral NeuroscienceCitation Excerpt :Substantia nigra–evoked responses, like those to stimulation of the cortex and thalamus, were consistently excitatory. Kocsis and Kitai (1977) showed that the synaptic response to substantia nigra stimulation was composed of an early short-latency (averaging about 3 ms) excitatory monosynaptic component and a longer-latency and more variable component that could not follow stimulation at rates higher than around 10/s. The latency of the fast monosynaptic EPSP did not match the axonal conduction velocity of the nigro-striatal neurons in substantia nigra pars compacta, measured by antidromic activation, which ranged from 10 to 15 ms in rats (eg, Guyenet and Aghajanian, 1978).
Striatal cholinergic dysfunction as a unifying theme in the pathophysiology of dystonia
2015, Progress in NeurobiologyCitation Excerpt :Whereas the massive vGluT2-positive thalamostriatal projection from Pf terminates exclusively in the striatal matrix (Herkenham and Pert, 1981; Sadikot et al., 1992b; Raju et al., 2006), the pattern of synaptic innervation of corticostriatal vGluT1-positive terminals does not differ between patch/striosome and matrix compartments (Raju et al., 2006). The convergence of thalamic and cortical inputs upon single MSNs is consistent with in vivo and in vitro electrophysiological analyses showing that single direct or indirect pathway neurons respond to both cortical and thalamic stimulation in rodents (Kocsis and Kitai, 1977; Vandermaelen and Kitai, 1980; Ding et al., 2008; Ellender et al., 2011, 2013; Huerta-Ocampo et al., 2013). Thalamic modulation of striatal ChI activity, by gating corticostriatal transmission, regulates behavioral switching and attentional set-shifting (Kimura et al., 2004; Ding et al., 2010; Smith et al., 2011; Sciamanna et al., 2012; Bradfield et al., 2013a,b).
An update on the connections of the ventral mesencephalic dopaminergic complex
2014, NeuroscienceCitation Excerpt :These workers also noted that mice appear to have a lesser GLU VTA projection to the mPfC than rats. Longstanding evidence for co-release of GLU from midbrain DA complex DA neurons and axons (Kocsis and Kitai, 1977; Sulzer et al., 1998; Joyce and Rayport, 2000; Chuhma et al., 2004; Dal Bo et al., 2004; Descarries et al., 2008; Broussard, 2012) has been bolstered by recent technical advances. Optical stimulation of DA terminals in the Acb shell, but not the dorsal striatum, of adult mice evokes GLU-mediated postsynaptic responses in MdSNs.